| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4011817 | Binding | Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system using FITC-labeled MCM2 peptide as substrate measured after 5 hrs in presence of 5 uM ATP | Homo sapiens | 31 | ALA4011589 | assay format | Scientific Literature | |
| 2. | ALA4011818 | ADME | Stability in human liver microsomes assessed as compound remaining at 1 uM in presence of NADPH after 30 mins by LC-MS/MS analysis | Homo sapiens | 8 | ALA4011589 | assay format | Scientific Literature | |
| 3. | ALA4011819 | ADME | Stability in rat liver microsomes assessed as compound remaining at 1 uM in presence of NADPH after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA4011589 | assay format | Scientific Literature | |
| 4. | ALA4011820 | Binding | ATP competitive inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system using FITC-labeled MCM2 peptide as substrate measured after 5 hrs in presence of varying levels of ATP | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 5. | ALA4011821 | Binding | ATP competitive inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system at 0.0001 to 0.1 uM using FITC-labeled MCM2 peptide as substrate pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 6. | ALA4011823 | Binding | Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system assessed as dissociation rate constant using FITC-labeled MCM2 peptide as substrate pretreated for 50 mins followed by substrate addition measured up to 500 mins by fluorescence assay | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 7. | ALA4011824 | Binding | Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system assessed as dissociation half life using FITC-labeled MCM2 peptide as substrate pretreated for 50 mins followed by substrate addition measured up to 500 mins by fluorescence assay | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 8. | ALA4011825 | Binding | Reversible inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system assessed as recovery of enzyme activity using FITC-labeled MCM2 peptide as substrate pretreated for 50 mins followed by substrate addition measured up to 500 mins by fluorescence assay | Homo sapiens | 2 | ALA4011589 | assay format | Scientific Literature | |
| 9. | ALA4011826 | Binding | Inhibition of ABL (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | single protein format | Scientific Literature | |
| 10. | ALA4011827 | Binding | Inhibition of ABL E255K mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 11. | ALA4011828 | Binding | Inhibition of ABL T315I mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 12. | ALA4011829 | Binding | Inhibition of ALK (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | single protein format | Scientific Literature | |
| 13. | ALA4011830 | Binding | Inhibition of ALK C1156Y mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 14. | ALA4011831 | Binding | Inhibition of ALK F1174L mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 15. | ALA4011832 | Binding | Inhibition of ALK G1202R mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 16. | ALA4011833 | Binding | Inhibition of ALK L1196M mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 17. | ALA4011834 | Binding | Inhibition of ALK R1275Q mutant (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | assay format | Scientific Literature | |
| 18. | ALA4011835 | Binding | Inhibition of NPM1/ALK (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | protein format | Scientific Literature | |
| 19. | ALA4011836 | Binding | Inhibition of ARG (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | single protein format | Scientific Literature | |
| 20. | ALA4011837 | Binding | Inhibition of BMX (unknown origin) at 0.1 uM pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATP relative to control | Homo sapiens | 1 | ALA4011589 | single protein format | Scientific Literature |
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