| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4018310 | B | Inhibition of recombinant human N-terminal His-tagged FGFR4 cytoplasmic domain (781 to 133 residues) expressed in baculovirus expression system using tyr 04 peptide as substrate measured within 90 mins by Z-LYTE assay | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 2. | ALA4018311 | A | Drug degradation in human plasma measured after 2 hrs by metabolite identification method | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 3. | ALA4018312 | A | Inhibition of recombinant human His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus expression system using tyr 04 as substrate measured within 60 mins by Z-LYTE assay | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 4. | ALA4018313 | P | Kinetic solubility of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4018314 | P | Octanol-buffer distribution co-efficient, log D of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4018315 | A | Apparent permeability from apical to basolateral side in MDCK2-MDR1 cells at 2 uM after 2.5 hrs LC-MS/MS analysis | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4018316 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK2-MDR1 cells at 2 uM after 2.5 hrs LC-MS/MS analysis | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4018317 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 9. | ALA4018318 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 10. | ALA4018319 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 11. | ALA4018320 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 12. | ALA4018321 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 13. | ALA4018322 | A | Stability in human plasma assessed as compound remaining at 2 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
| 14. | ALA4018323 | A | Stability in mouse plasma assessed as compound remaining at 2 uM measured after 2 hrs by LC-MS/MS analysis | Mus musculus | 9 | cell-free format | Scientific Literature | ||
| 15. | ALA4018324 | A | Intrinsic clearance in human liver microsomes at 1 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 16. | ALA4018325 | A | Intrinsic clearance in mouse liver microsomes at 1 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 7 | assay format | Scientific Literature | ||
| 17. | ALA4018326 | A | Inhibition of human VEGFR2 at 10 uM using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic method relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4018327 | B | Inhibition of human EGFR at 10 uM using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic method relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA4018328 | B | Inhibition of human BTK at 10 uM using KVEKIGEGTYGVVYK as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic method relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA4018329 | B | Inhibition of human FMS at 10 uM using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic method relative to control | Homo sapiens | 3 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!