# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4000086 | Functional | Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method | Mus musculus | 45 | ALA3997854 | cell-based format | Scientific Literature | |
2. | ALA4000087 | Functional | Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay | Homo sapiens | 45 | ALA3997854 | cell-based format | Scientific Literature | |
3. | ALA4000088 | Physicochemical | Kinetic solubility in pH 2 PBS buffer at 100 uM after 4 hrs by UV-HPLC analysis | 17 | ALA3997854 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4000089 | Physicochemical | Kinetic solubility in pH 7.4 PBS buffer at 100 uM after 4 hrs by UV-HPLC analysis | 17 | ALA3997854 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4000096 | Functional | Glucose lowering effect in C57BL/6J mouse assessed as decrease in blood glucose AUC at 30 mg/kg, po administered as single dose 30 mins prior to glucose challenge measured after 120 mins by OGTT relative to control | Mus musculus | 10 | ALA3997854 | organism-based format | Scientific Literature | |
6. | ALA4000097 | ADME | Plasma concentration in C57BL/6J mouse at 30 mg/kg, po measured at 2 hrs post dose by LC-MS/MS analysis | Mus musculus | 10 | ALA3997854 | organism-based format | Scientific Literature |