# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4040504 | B | Displacement of [3H]JNJ-46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as association rate constant measured every 30 sec for 120 mins by scintillation proximity assay | Homo sapiens | 45 | ALA4038323 | cell-based format | Scientific Literature | |
2. | ALA4040505 | B | Displacement of [3H]JNJ-46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as dissociation rate constant measured every 30 sec for 120 mins by scintillation proximity assay | Homo sapiens | 45 | ALA4038323 | cell-based format | Scientific Literature | |
3. | ALA4040506 | B | Displacement of [3H]JNJ-46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as residence time measured every 30 sec for 120 mins by scintillation proximity assay | Homo sapiens | 45 | ALA4038323 | cell-based format | Scientific Literature | |
4. | ALA4040507 | B | Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay | Homo sapiens | 45 | ALA4038323 | cell-based format | Scientific Literature | |
5. | ALA4040508 | F | Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 30 mins by Topcount scintillation counting method | Homo sapiens | 45 | ALA4038323 | cell-based format | Scientific Literature | |
6. | ALA4040510 | B | Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting analysis | Homo sapiens | 41 | ALA4038323 | cell-based format | Scientific Literature | |
7. | ALA4040511 | F | Agonist activity at human metabotropic glutamate receptor 1 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
8. | ALA4040512 | F | Antagonist activity at human metabotropic glutamate receptor 1 expressed in HEK293 cells assessed as inhibition of glutamate-induced Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
9. | ALA4040513 | F | Agonist activity at human metabotropic glutamate receptor 3 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
10. | ALA4040514 | F | Antagonist activity at human metabotropic glutamate receptor 3 expressed in HEK293 cells assessed as inhibition of glutamate-induced Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
11. | ALA4040515 | F | Agonist activity at human metabotropic glutamate receptor 5 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
12. | ALA4040516 | F | Antagonist activity at human metabotropic glutamate receptor 5 expressed in HEK293 cells assessed as inhibition of glutamate-induced Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
13. | ALA4040517 | F | Positive allosteric modulation of human metabotropic glutamate receptor 5 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr in the presence of glutamate by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
14. | ALA4040518 | F | Agonist activity at human metabotropic glutamate receptor 7 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
15. | ALA4040519 | F | Antagonist activity at human metabotropic glutamate receptor 7 expressed in HEK293 cells assessed as inhibition of glutamate-induced Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
16. | ALA4040520 | F | Agonist activity at human metabotropic glutamate receptor 8 expressed in HEK293 cells assessed as induction of Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
17. | ALA4040521 | F | Antagonist activity at human metabotropic glutamate receptor 8 expressed in HEK293 cells assessed as inhibition of glutamate-induced Ca2+ internalization after 1 hr by fluo-4-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4038323 | cell-based format | Scientific Literature | |
18. | ALA4040522 | F | Agonist activity at human metabotropic glutamate receptor 4 assessed as increase in [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 30 mins by Topcount scintillation counting method | Homo sapiens | 4 | ALA4038323 | single protein format | Scientific Literature | |
19. | ALA4040523 | F | Antagonist activity at human metabotropic glutamate receptor 4 assessed as inhibition of glutamate-induced [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 30 mins by Topcount scintillation counting method | Homo sapiens | 4 | ALA4038323 | single protein format | Scientific Literature | |
20. | ALA4040524 | F | Agonist activity at rat metabotropic glutamate receptor 6 expressed in CHO cell membranes assessed as increase in [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 30 mins by Topcount scintillation counting method | Rattus norvegicus | 4 | ALA4038323 | cell-based format | Scientific Literature |