| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4029647 | B | Inhibition of full length recombinant mouse N-terminal GST-tagged PAD2 expressed in baculovirus infected Sf9 cells using benzoyl arginine ethyl ester as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA4029648 | B | Inhibition of full length recombinant human N-terminal GST-tagged PAD4 expressed in baculovirus infected Sf9 cells using benzoyl arginine ethylester as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4029650 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as improvement in physical disability at 100 mg/kg, ip administered once daily for 40 days measured daily during compound dosing | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA4029651 | T | Toxicity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as change in body weight at 50 mg/kg, ip administered once daily for 40 days measured during compound dosing | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4029652 | T | Toxicity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as death at 50 mg/kg, ip administered once daily for 40 days measured during compound dosing (Rvb = 20%) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4029653 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in accumulation of CD3 positive cells in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA4029654 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in accumulation of MAC3 positive cells in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA4029655 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as increase in myelin content at 100 mg/kg, ip administered once daily for 40 days measured post last dose by LFB /H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4029656 | F | Antiinflammatory activity MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in scar tissue around blood vessels in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose by LFB/H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4029657 | A | Elimination rate constant in C57BL/6 mouse brain at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4029658 | A | Elimination rate constant in C57BL/6 mouse serum at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4029659 | A | AUC (0 to 360 mins) in C57BL/6 mouse serum at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4029660 | F | Neuroprotective activity in CPZ-induced demyelination C57BL/6 mouse model assessed as increase in myelin content at 100 mg/kg, ip dosed daily for 6 weeks measured post last dose by LFB staining based immunohistochemical method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4029661 | A | Half life in C57BL/6 mouse serum at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4029662 | A | Cmax in C57BL/6 mouse serum at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4029663 | A | Tmax in C57BL/6 mouse serum at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4029664 | A | Half life in C57BL/6 mouse brain at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4029665 | A | Cmax in C57BL/6 mouse brain at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4029666 | A | Tmax in C57BL/6 mouse brain at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4029667 | A | AUC (0 to 360 mins) in C57BL/6 mouse brain at 100 mg/kg, ip administered as single dose by UPLC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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