# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4035251 | Functional | Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation at 100 uM preincubated for 2 mins followed by arachidonic acid addition by turbidimetric method relative to control | Homo sapiens | 21 | ALA4033666 | cell-based format | Scientific Literature | |
2. | ALA4035252 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation at 100 uM preincubated for 2 mins followed by ADP addition by turbidimetric method relative to control | Homo sapiens | 21 | ALA4033666 | cell-based format | Scientific Literature | |
3. | ALA4035253 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation at 100 uM preincubated for 2 mins followed by collagen addition by turbidimetric method relative to control | Homo sapiens | 21 | ALA4033666 | cell-based format | Scientific Literature | |
4. | ALA4035254 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of epinephrine-induced platelet aggregation at 100 uM preincubated for 2 mins followed by epinephrine addition by turbidimetric method relative to control | Homo sapiens | 21 | ALA4033666 | cell-based format | Scientific Literature | |
5. | ALA4035255 | Functional | Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 2 mins followed by arachidonic acid addition by turbidimetric method relative to control | Homo sapiens | 8 | ALA4033666 | cell-based format | Scientific Literature | |
6. | ALA4035256 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 2 mins followed by ADP addition by turbidimetric method | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
7. | ALA4035257 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 2 mins followed by collagen addition by turbidimetric method | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
8. | ALA4035258 | ADME | Antiplatelet activity in human platelet rich plasma assessed as inhibition of epinephrine-induced platelet aggregation preincubated for 2 mins followed by epinephrine addition by turbidimetric method | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
9. | ALA4035259 | ADME | Inhibition of ovine COX-1 assessed as reduction in PGH2 production up to 100 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hematin addition measured after 2 mins by ELISA relative to control | Ovis aries | 6 | ALA4033666 | single protein format | Scientific Literature | |
10. | ALA4035260 | ADME | Inhibition of recombinant human COX-2 assessed as reduction in PGH2 production up to 100 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hematin addition measured after 2 mins by ELISA relative to control | Homo sapiens | 6 | ALA4033666 | single protein format | Scientific Literature | |
11. | ALA4035261 | Binding | Inhibition of TXS in human platelet rich plasma assessed as decrease in TXB2 production at 100 uM using arachidonic acid after 5 mins by ELISA | Homo sapiens | 8 | ALA4033666 | assay format | Scientific Literature | |
12. | ALA4035263 | Functional | Potency index, ratio of aspirin IC50 to test compound IC50 for inhibition of arachidonic acid-induced platelet aggregation in human platelet rich plasma | Homo sapiens | 5 | ALA4033666 | cell-based format | Scientific Literature | |
13. | ALA4035264 | Binding | Binding affinity to DOPC/DOPS large unilamellar vesicles assessed as blue shift at 100 uM by DAPI staining based fluorescence assay | 6 | ALA4033666 | assay format | Scientific Literature | ||
14. | ALA4035265 | ADME | Drug uptake in human platelet assessed as co-localization with CD31 at 100 uM by epifluorescence assay | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
15. | ALA4035266 | ADME | Drug uptake in human platelet assessed as co-localization with CD31 at 100 uM by confocal microscopy analysis | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
16. | ALA4035267 | ADME | Hemolytic activity against human erythrocytes after 3 hrs relative to control | Homo sapiens | 7 | ALA4033666 | cell-based format | Scientific Literature | |
17. | ALA4035268 | ADME | Inhibition of recombinant human CYP3A4 expressed in baculosomes using BOMR as substrate preincubated for 10 mins followed by substrate/NADP+ addition measured for 1 hr | Homo sapiens | 6 | ALA4033666 | assay format | Scientific Literature | |
18. | ALA4035270 | Functional | Antiplatelet activity in human platelet rich plasma assessed as inhibition of U44619-induced platelet aggregation at 100 uM preincubated for 2 mins followed by U44619 addition by turbidimetric method | Homo sapiens | 6 | ALA4033666 | cell-based format | Scientific Literature | |
19. | ALA4035271 | ADME | Reduction of clot retraction in human whole blood after 2 hrs | Homo sapiens | 6 | ALA4033666 | tissue-based format | Scientific Literature | |
20. | ALA4035272 | ADME | Change in prothrombin time in human plasma at 100 uM incubated for 15 mins at room temperature and 2 mins at 37 degC in presence of calcium thromboplastin | Homo sapiens | 20 | ALA4033666 | cell-free format | Scientific Literature |