Pyrogenic activity in Chinchilla rabbit assessed as change in maximum body temperature at 100 nmol/kg, iv using micellar foemulation measured at 30 mins time intervals
Immuno-stimulatory activity in ICR mouse assessed as induction of GM-progenitor cell proliferation in serum at 100 nmol/kg, sc using liposomal formulation measured after 6 hrs
Pyrogenic activity in New Zealand albino rabbit assessed as change in maximum body temperature at 100 nmol/kg, sc using liposomal formulation measured at 30 mins time intervals for 9 to 24 hrs (Rvb = 0.2 degC)
Toxicity in Chinchilla rabbit assessed as necrosis at site of application at 100 nmol/kg, iv using micellar formulation measured up to 2 months post dose
Toxicity in New Zealand albino rabbit assessed as necrosis at site of application at 100 nmol/kg, sc using liposomal formulation measured up to 2 months post dose
Agonist activity at human NOD2 receptor expressed in mouse Raw-Blue reporter cells at 10 uM after 48 hrs in presence of GSK717 by SEAP reporter gene assay
Agonist activity at human NOD2 receptor expressed in mouse Raw-Blue reporter cells at 10 uM after 48 hrs in presence of gefitinib by SEAP reporter gene assay