# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4031112 | Binding | Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | Homo sapiens | 17 | ALA4028858 | single protein format | Scientific Literature | |
2. | ALA4031116 | Functional | Induction of apoptosis in KRAS-dependent human Capan1 cells at 25 uM incubated for 48 hrs by Annexin-V FITC/propidium iodide staining-based flow cytometry relative to control | Homo sapiens | 3 | ALA4028858 | cell-based format | Scientific Literature | |
3. | ALA4031117 | Functional | Induction of apoptosis in KRAS-dependent human Capan1 cells at 50 uM incubated for 48 hrs by Annexin-V FITC/propidium iodide staining-based flow cytometry relative to control | Homo sapiens | 1 | ALA4028858 | cell-based format | Scientific Literature | |
4. | ALA4031120 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced AKT phosphorylation at Ser473 at 25 uM after 1 hr by Western blot method | Homo sapiens | 1 | ALA4028858 | assay format | Scientific Literature | |
5. | ALA4031121 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced ERK phosphorylation at Thr202/Thr204 at 25 uM after 1 hr by Western blot method | Homo sapiens | 1 | ALA4028858 | assay format | Scientific Literature | |
6. | ALA4031125 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as increase in endogenous RAS distribution to endomembranes at 25 uM incubated for 2 hrs by immunofluorescence staining based method | Homo sapiens | 2 | ALA4028858 | assay format | Scientific Literature | |
7. | ALA4031127 | Functional | Downregulation of PDEdelta protein expression in KRAS-dependent human Capan1 cells at 25 uM incubated for 2 hrs by immunofluorescence staining-based method | Homo sapiens | 1 | ALA4028858 | cell-based format | Scientific Literature |