| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4032890 | B | Inhibition of TC-PTP (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA4032891 | B | Selectivity ratio of IC50 for SHP1 (unknown origin) expressed in Escherichia coli BL21(DE3) to IC50 for SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA4032892 | B | Inhibition of SHP1 (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4032893 | B | Allosteric inhibition of SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 5. | ALA4032894 | B | Allosteric inhibition of 2P-IRS-1 stimulated wild type SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA4032895 | B | Allosteric inhibition of SHP2 PTP domain (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA4032896 | B | Inhibition of LMW-PTP (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4032897 | B | Inhibition of MKP3 (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4032898 | B | Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4032899 | B | Inhibition of CDC25A (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4032900 | B | Inhibition of VHR (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4032901 | B | Selectivity ratio of IC50 for LMW-PTP (unknown origin) expressed in Escherichia coli BL21(DE3) to IC50 for SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4032902 | B | Selectivity ratio of IC50 for MKP3 (unknown origin) expressed in Escherichia coli BL21(DE3) to IC50 for SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4032903 | B | Selectivity ratio of IC50 for PTP1B (unknown origin) expressed in Escherichia coli BL21(DE3) to IC50 for SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4032904 | B | Selectivity ratio of IC50 for TC-PTP (unknown origin) expressed in Escherichia coli BL21(DE3) to IC50 for SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4032905 | B | Inhibition of SHP2 N58S mutant (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4032906 | B | Allosteric inhibition of SHP2 in human NCI-H661 cells assessed as downregulation of phosphorylated ERK1/2 levels at 2.5 to 20 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4032907 | B | Allosteric inhibition of SHP2 in human NCI-H661 cells assessed as downregulation of phosphorylated AKT levels at 2.5 to 20 uM after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4032910 | B | Allosteric inhibition of SHP2 in human NCI-H661 cells assessed as downregulation of ERK1/2 activation at 10 uM after 60 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4032911 | B | Allosteric inhibition of SHP2 in human NCI-H661 cells assessed as downregulation of ERK1/2 activation at 10 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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