# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4042358 | Binding | Uncompetitive inhibition of Trypanosoma cruzi trypanothione reductase using T(SH)2 as substrate at pH 7.5 in presence of NADPH by photometric method | Trypanosoma cruzi | 14 | ALA4041512 | single protein format | Scientific Literature | |
2. | ALA4042359 | Binding | Inhibition of Trypanosoma cruzi trypanothione reductase at 100 uM using T(SH)2 as substrate at pH 7.5 in presence of NADPH by photometric method | Trypanosoma cruzi | 4 | ALA4041512 | single protein format | Scientific Literature | |
3. | ALA4042360 | Functional | Anti-parasitic activity against Trypanosoma cruzi Dm28c epimastigotes in logarithmic phase measured after 24 to 48 hrs by resazurin assay | Trypanosoma cruzi | 14 | ALA4041512 | assay format | Scientific Literature | |
4. | ALA4042361 | ADME | Cytotoxicity against human HeLa cells measured after 24 hrs by crystal violet staining based assay | Homo sapiens | 9 | ALA4041512 | cell-based format | Scientific Literature | |
5. | ALA4042362 | Toxicity | Selectivity index, ratio of EC50 for cytotoxicity against human HeLa cells to IC50 for anti-parasitic activity against Trypanosoma cruzi Dm28c epimastigotes | 9 | ALA4041512 | cell-based format | Scientific Literature | ||
6. | ALA4042364 | Functional | Potency index, ratio of nifurtimox IC50 to test compound IC50 for Trypanosoma cruzi Dm28c epimastigotes in logarithmic phase | Trypanosoma cruzi | 1 | ALA4041512 | assay format | Scientific Literature |