| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4037917 | B | Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPilight pyrophosphate-detection based assay | Homo sapiens | 34 | single protein format | Scientific Literature | ||
| 2. | ALA4037918 | P | Solubility of the compound in buffer | 34 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4037919 | A | Intrinsic clearance in mouse liver microsomes at 1 mM preincubated for 5 mins followed by NADPH addition measured by LC-MS/MS analysis | Mus musculus | 17 | assay format | Scientific Literature | ||
| 4. | ALA4037920 | A | Drug metabolism in mouse liver microsomes at 1 mM preincubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Mus musculus | 17 | assay format | Scientific Literature | ||
| 5. | ALA4037921 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 6. | ALA4037922 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA4037923 | A | Efflux ratio of permeability in human Caco2 cells at 10 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 8. | ALA4037928 | B | Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC after 60 mins by cellular thermal shift assay | Homo sapiens | 6 | cell-based format | Scientific Literature |
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