# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4041776 | F | Trypanocidal activity against Trypanosoma cruzi TCC epimastigotes assessed as parasite duplication time at 1 to 15 uM supplemented with fresh medium containing compound every 9 to 10 days measured on third week | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
2. | ALA4041777 | F | Trypanocidal activity against Trypanosoma cruzi TCC epimastigotes assessed as maximal parasite density at 1 to 15 uM supplemented with fresh medium containing compound every 9 to 10 days measured on third week by haemocytometric method | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
3. | ALA4041778 | F | Trypanocidal activity against Trypanosoma cruzi TCC epimastigotes assessed as effect on parasite motility at 1 to 15 uM supplemented with fresh medium containing compound every 9 to 10 days measured on third week | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
4. | ALA4041779 | F | Trypanocidal activity against Trypanosoma cruzi TCC epimastigotes assessed as effect on parasite viability at 1 to 15 uM supplemented with fresh medium containing compound every 9 to 10 days measured on third week by maximal parasite density | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
5. | ALA4041780 | F | Trypanocidal activity against Trypanosoma cruzi RA tripamastigote bloodstream forms isolated from infected CF1 mouse blood after 24 hrs by haemocytometric method | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
6. | ALA4041781 | A | Cytotoxicity against mouse RAW cells assessed as reduction in cell viability after 24 hrs by MTT assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
7. | ALA4041782 | F | Trypanocidal activity against Trypanosoma cruzi RA tripamastigote bloodstream forms infected in Balb/c mouse assessed as reduction in circulating parasite level in acute phase at 100 mg/kg, po administered on day 9 post infection for 5 consecutive days | Trypanosoma cruzi | 2 | organism-based format | Scientific Literature | ||
8. | ALA4041783 | F | Trypanocidal activity against Trypanosoma cruzi RA tripamastigote bloodstream forms infected in Balb/c mouse assessed as reduction in parasitaemia at 100 mg/kg, po administered on day 9 post infection for 5 consecutive days measured on day 35 post infection relative to control | Trypanosoma cruzi | 3 | organism-based format | Scientific Literature | ||
9. | ALA4041784 | F | Trypanocidal activity against Trypanosoma cruzi RA tripamastigote bloodstream forms infected in Balb/c mouse assessed as mouse survival at 100 mg/kg, po administered on day 9 post infection for 5 consecutive days measured daily during compound dosing up to 45 days post infection | Trypanosoma cruzi | 3 | organism-based format | Scientific Literature |