# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3995517 | Functional | Agonist activity at human GPR39 expressed in HEK293 cells co-expressing Galphaq assessed as myo-[2-3H]inositol phosphate accumulation measured after 75 mins by scintillation proximity assay | Homo sapiens | 38 | ALA3994609 | cell-based format | Scientific Literature | |
2. | ALA3995519 | Functional | Agonist activity at human GPR39 expressed in HEK293 cells co-expressing Galphaq assessed as myo-[2-3H]inositol phosphate accumulation in presence of 10 uM Zn2+ measured after 75 mins by scintillation proximity assay | Homo sapiens | 38 | ALA3994609 | cell-based format | Scientific Literature | |
3. | ALA3995520 | Functional | Agonist activity at mouse GPR39 expressed in HEK293 cells co-expressing Galphaq assessed as myo-[2-3H]inositol phosphate accumulation measured after 75 mins by scintillation proximity assay | Mus musculus | 2 | ALA3994609 | cell-based format | Scientific Literature | |
4. | ALA3995528 | ADME | Intrinsic clearance in human liver microsomes assessed per mg protein at 3 uM measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA3994609 | assay format | Scientific Literature | |
5. | ALA3995529 | ADME | Half life in human liver microsomes at 3 uM measured by LC-MS/MS analysis | Homo sapiens | 2 | ALA3994609 | assay format | Scientific Literature | |
6. | ALA3995539 | Functional | Induction of glucose-stimulated insulin release in mouse pancreatic islets at 1 uM pretreated for 24 hrs followed by glucose addition measured after 30 mins | Mus musculus | 2 | ALA3994609 | cell-based format | Scientific Literature |