| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4040270 | F | Protection against tunicamycin ER stress-induced suppression of PDX1 mRNA expression in rat INS-1 cells up to 1 uM after 24 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 2. | ALA4040271 | A | Effect on CHOP mRNA level in rat INS-1 cells up to 10 uM after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 3. | ALA4040272 | A | Effect on ATF4 mRNA level in rat INS-1 cells up to 10 uM after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 4. | ALA4040273 | F | Antidiabetic activity in STZ-induced diabetic C57BL/6 mouse model assessed as total pancreatic islet beta-cell area at 5 mg/kg, ip administrated qd with streptozotocin for 5 days followed by compound administration alone for 2 more weeks by DAPI-staining based confocal microscopic analysis (Rvb = 30.2 +/- 7.9%) | Mus musculus | 1 | ALA4038317 | organism-based format | Scientific Literature | |
| 5. | ALA4040274 | F | Cytoprotective activity in rat INS-1 cells assessed as protection against tunicamycin-induced ER stress-mediated reduction in cell viability after 3 days by CellTiter-Glo assay | Rattus norvegicus | 42 | ALA4038317 | cell-based format | Scientific Literature | |
| 6. | ALA4040275 | F | Cytoprotective activity in rat INS-1 cells assessed as protection against tunicamycin-induced ER stress-mediated reduction in cell viability after 3 days by CellTiter-Glo assay relative tunicamycin | Rattus norvegicus | 47 | ALA4038317 | cell-based format | Scientific Literature | |
| 7. | ALA4040276 | F | Cytoprotective activity in rat INS-1 cells assessed as protection against tunicamycin-induced ER stress-mediated reduction reduction in cell viability up to 10 uM after 3 days by MTT assay | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 8. | ALA4040277 | F | Cytoprotective activity in mouse BetaTC6 cells assessed as protection against tunicamycin-induced ER stress-mediated reduction in cell viability after 3 days by CellTiter-Glo assay | Mus musculus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 9. | ALA4040278 | A | Cytotoxicity against rat INS-1 cells assessed as reduction in cell viability up to 10 uM after 3 days by CellTiter-Glo assay | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 10. | ALA4040279 | A | Cytotoxicity against mouse BetaTC6 cells assessed as reduction in cell viability up to 40 uM after 3 days by CellTiter-Glo assay | Mus musculus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 11. | ALA4040280 | F | Cytoprotective activity against tunicamycin ER stress-induced apoptosis in rat INS-1 cells assessed as inhibition of tunicamycin-induced cleaved caspase3 expression up to 1 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 12. | ALA4040281 | F | Cytoprotective activity against tunicamycin ER stress-induced apoptosis in rat INS-1 cells assessed as inhibition of tunicamycin-induced cleaved PARP expression up to 1 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 13. | ALA4040282 | F | Cytoprotective activity against tunicamycin ER stress-induced apoptosis in rat INS-1 cells assessed as viable cells at 0.1 uM after 48 hrs by phase contrast microscopic analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 14. | ALA4040283 | F | Cytoprotective activity against tunicamycin ER stress-induced apoptosis in rat INS-1 cells assessed as TUNEL positive cells at 0.1 to 1 uM after 24 hrs by TUNEL/DAPI-based microscopic analysis (Rvb = 7%) | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 15. | ALA4040284 | F | Protection against tunicamycin ER stress-induced suppression of INS1 mRNA expression in rat INS-1 cells up to 1 uM after 24 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 16. | ALA4040285 | F | Protection against tunicamycin ER stress-induced suppression of INS2 mRNA expression in rat INS-1 cells up to 1 uM after 24 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 17. | ALA4040286 | F | Protection against tunicamycin ER stress-induced suppression of MafA mRNA expression in rat INS-1 cells up to 1 uM after 24 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 18. | ALA4040287 | F | Protection against tunicamycin ER stress-induced suppression of glucose-stimulated insulin secretion in rat INS-1 cells after 24 hrs by ELISA | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 19. | ALA4040288 | B | Inhibition of PERK activation in rat INS-1 cells assessed as suppression of tunicamycin-induced increase in ATF4 mRNA levels up to 10 uM after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature | |
| 20. | ALA4040289 | B | Inhibition of PERK activation in rat INS-1 cells assessed as suppression of tunicamycin-induced CHOP mRNA expression after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4038317 | cell-based format | Scientific Literature |
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