| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4018132 | Functional | Potency index, ratio of ribavirin IC50 to compound IC50 for HSV-1 L2 infected in African green monkey Vero E6 cells | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 2. | ALA4018133 | Functional | Antiviral activity against acyclovir-resistant HSV-1 L2 infected in African green monkey Vero E6 cells assessed as viral reproduction at 52 uM measured after 48 hrs post infection by gentian violet staining based plaque reduction assay (Rvb = 5.95 +/- 0.03 log10PFU/ml) | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 3. | ALA4018134 | ADME | Cytotoxicity against African green monkey Vero E6 cells measured after 3 days by trypan blue assay | Chlorocebus sabaeus | 7 | ALA4017472 | cell-based format | Scientific Literature | |
| 4. | ALA4018135 | Functional | Antiviral activity against HSV1 L2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 7 | ALA4017472 | assay format | Scientific Literature | |
| 5. | ALA4018136 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for HSV-1 L2 infected in African green monkey Vero E6 cells | 7 | ALA4017472 | assay format | Scientific Literature | ||
| 6. | ALA4018137 | Functional | Potency index, ratio of maribavir IC50 to compound IC50 for HSV-1 L2 infected in African green monkey Vero E6 cells | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 7. | ALA4018138 | Functional | Antiviral activity against acyclovir-resistant HSV-1 L2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 5 | ALA4017472 | assay format | Scientific Literature | |
| 8. | ALA4018139 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for acyclovir-resistant HSV-1 L2 infected in African green monkey Vero E6 cells | 5 | ALA4017472 | assay format | Scientific Literature | ||
| 9. | ALA4018140 | Functional | Antiviral activity against HSV-1 L2/Rp-ACV/2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 5 | ALA4017472 | assay format | Scientific Literature | |
| 10. | ALA4018141 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for HSV-1 L2/Rp-ACV/2 infected in African green monkey Vero E6 cells | 5 | ALA4017472 | assay format | Scientific Literature | ||
| 11. | ALA4018142 | Functional | Antiviral activity against foscarnet-resistant HSV-1 F+ infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 5 | ALA4017472 | assay format | Scientific Literature | |
| 12. | ALA4018143 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for HSV-1 F+ infected in African green monkey Vero E6 cells | 5 | ALA4017472 | assay format | Scientific Literature | ||
| 13. | ALA4018144 | Functional | Antiviral activity against acyclovir and foscarnet-resistant HSV-1 L2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 5 | ALA4017472 | assay format | Scientific Literature | |
| 14. | ALA4018145 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for acyclovir and foscarnet-resistant HSV-1 L2 infected in African green monkey Vero E6 cells | 5 | ALA4017472 | assay format | Scientific Literature | ||
| 15. | ALA4018146 | Functional | Antiviral activity against acyclovir and cidofovir-resistant HSV-1 L2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect | Human alphaherpesvirus 1 | 5 | ALA4017472 | assay format | Scientific Literature | |
| 16. | ALA4018147 | Unassigned | Selectivity index, ratio of MCC for African green monkey Vero E6 cells to IC50 for acyclovir and cidofovir-resistant HSV-1 L2 infected in African green monkey Vero E6 cells | 5 | ALA4017472 | assay format | Scientific Literature | ||
| 17. | ALA4018148 | Functional | Antiviral activity against HSV-1 L2 infected in African green monkey Vero E6 cells assessed as viral reproduction at 52 uM measured after 48 hrs post infection by gentian violet staining based plaque reduction assay (Rvb = 6.91 +/- 0.05 log10PFU/ml) | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 18. | ALA4018149 | Functional | Antiviral activity against HSV-1 L2/Rp-ACV/2 infected in African green monkey Vero E6 cells assessed as viral reproduction at 52 uM measured after 48 hrs post infection by gentian violet staining based plaque reduction assay (Rvb = 6.05 +/- 0.1 log10PFU/ml) | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 19. | ALA4018150 | Functional | Antiviral activity against foscarnet-resistant HSV-1 F+ infected in African green monkey Vero E6 cells assessed as viral reproduction at 52 uM measured after 48 hrs post infection by gentian violet staining based plaque reduction assay (Rvb = 6.6 +/- 0.1 log10PFU/ml) | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature | |
| 20. | ALA4018151 | Functional | Antiviral activity against acyclovir and foscarnet-resistant HSV-1 L2 infected in African green monkey Vero E6 cells assessed as viral reproduction at 52 uM measured after 48 hrs post infection by gentian violet staining based plaque reduction assay (Rvb = 5.92 +/- 0.11 log10PFU/ml) | Human alphaherpesvirus 1 | 1 | ALA4017472 | assay format | Scientific Literature |
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