| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4038125 | B | Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Homo sapiens | 13 | single protein format | Scientific Literature | ||
| 2. | ALA4038126 | B | Inhibition of cynomolgus monkey plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Macaca fascicularis | 5 | assay format | Scientific Literature | ||
| 3. | ALA4038127 | B | Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Mus musculus | 5 | single protein format | Scientific Literature | ||
| 4. | ALA4038128 | B | Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Rattus norvegicus | 7 | single protein format | Scientific Literature | ||
| 5. | ALA4038129 | B | Inhibition of rabbit plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Oryctolagus cuniculus | 5 | assay format | Scientific Literature | ||
| 6. | ALA4038130 | B | Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Sus scrofa | 5 | single protein format | Scientific Literature | ||
| 7. | ALA4038131 | B | Inhibition of dog plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay | Canis lupus familiaris | 5 | assay format | Scientific Literature | ||
| 8. | ALA4038132 | A | Half life in human plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 9. | ALA4038133 | A | Half life in mouse plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 10. | ALA4038134 | A | Half life in rat plasma at 4 uM measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 11. | ALA4038135 | A | Half life in human vitreous humor at 1 uM measured up to 24 hrs by LC-MS/MS analysis | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 12. | ALA4038136 | A | Drug metabolism in rat plasma assessed as (5R,8S,11S,14S,17S,20S,23R)-29-[[(2R)-2-acetamido-3-hydroxy-3-oxo-propyl]sulfanylmethyl]-5-amino-14-(3-amino-3-oxo-propyl)-17-(carboxymethyl)-11-(1H-imidazol-5-ylmethyl)-8,20-diisobutyl-6,9,12,15,18,21-hexaoxo-3,25-dithia-7,10,13,16,19,22-hexazabicyclo[25.3.1]hentriaconta-1(31),27,29-triene-23-carboxylic acid metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA4038137 | A | Drug metabolism in rat plasma assessed as (5R,8S,11S,14S,17S,20S,23R)-29-[[(2R)-2-acetamido-3-[[(1S)-2-hydroxy-1-(hydroxymethyl)-2-oxo-ethyl]amino]-3-oxo-propyl]sulfanylmethyl]-5-amino-14-(3-amino-3-oxo-propyl)-17-(carboxymethyl)-11-(1H-imidazol-5-ylmethyl)-8,20-diisobutyl-6,9,12,15,18,21-hexaoxo-3,25-dithia-7,10,13,16,19,22-hexazabicyclo[25.3.1]hentriaconta-1(31),27,29-triene-23-carboxylic acid metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA4038162 | A | Plasma clearance in Sprague-Dawley rat at 10 mg/kg, iv administered as infusion over 1 hr measured up to 240 mins post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4038165 | F | Antiinflammatory activity in Sprague-Dawley rat carrageenan-induced paw edema model assessed as inhibition of paw edema AUC (0 to 2 hrs) at 10 to 30 mg/kg, ip pretreated for 15 mins followed by carrageenan challenge | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4038177 | A | Drug metabolism in rat plasma assessed as (5R,8S,11S,14S,17S,20S,23R)-29-[[(2R)-2-acetamido-3-[[(1S)-1-(hydroxymethyl)-2-[[(1S)-2-[(2S)-2-[[(1S)-2-hydroxy-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-3-oxo-propyl]sulfanylmethyl]-5-amino-14-(3-amino-3-oxo-propyl)-17-(carboxymethyl)-11-(1H-imidazol-5-ylmethyl)-8,20-diisobutyl-6,9,12,15,18,21-hexaoxo-3,25-dithia-7,10,13,16,19,22-hexazabicyclo[25.3.1]hentriaconta-1(31),27,29-triene-23-carboxylic acid metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 17. | ALA4038178 | A | Drug metabolism in human plasma assessed as deltaL6H7Q6 metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 18. | ALA4038179 | A | Drug metabolism in human plasma assessed as deltaH7Q6 metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 19. | ALA4038180 | A | Drug metabolism in human plasma assessed as deltaLeu6 metabolite formation at 50 uM after 18 hrs by MALDI-TOF analysis | Homo sapiens | 1 | cell-free format | Scientific Literature |
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