#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4027223	B	Inhibition of human recombinant PDE1A expressed insect sf9 cells by radiometric assay	Homo sapiens	2		cell-based format	Scientific Literature
2.	ALA4027224	A	Protein binding in human plasma at 5 uM after 5 hrs by LC-MS/MS analysis	Homo sapiens	10		cell-free format	Scientific Literature
3.	ALA4027225	B	Inhibition of PDE4 in human U937 cell lysates assessed as residual cAMP after 2.5 mins by LANCE assay	Homo sapiens	34		assay format	Scientific Literature
4.	ALA4027226	B	Inhibition of PDE4 in human PBMC assessed as reduction in LPS-induced TNFalpha release after 18 hrs by quantitative ELISA	Homo sapiens	33		assay format	Scientific Literature
5.	ALA4027227	A	Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis	Homo sapiens	10		cell-based format	Scientific Literature
6.	ALA4027228	A	Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis	Homo sapiens	10		cell-based format	Scientific Literature
7.	ALA4027229	A	Intrinsic clearance in human liver microsomes at 1 uM measured after 60 mins in presence NADPH by LC-MS/MS analysis	Homo sapiens	10		assay format	Scientific Literature
8.	ALA4027230	A	Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM measured after 90 mins by LC-MS/MS analysis	Homo sapiens	10		cell-based format	Scientific Literature
9.	ALA4027231	A	Metabolic stability in human lung S9 fraction assessed as compound remaining at 1 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis	Homo sapiens	10		assay format	Scientific Literature
10.	ALA4027232	A	Metabolic stability in human plasma assessed as compound remaining at 1 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis	Homo sapiens	10		cell-free format	Scientific Literature
11.	ALA4027234	F	Anti-inflammatory activity in OVA-induced airway inflammation Brown Norway rat model assessed inhibition of eosinophils recruitment in bronchoalveolar lavage fluid administered intratracheally as powder formulation 2 hrs before aerosolized OVA challenge measured at 24 hrs post aerosolized OVA challenge	Rattus norvegicus	3		assay format	Scientific Literature
12.	ALA4027236	A	Stability in human hepatocytes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS/MS analysis	Homo sapiens	2		cell-based format	Scientific Literature
13.	ALA4027237	A	Drug metabolism in human hepatocytes assessed as (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide metabolite formation at 10 uM after 60 mins by LC-MS/MS analysis	Homo sapiens	2		cell-based format	Scientific Literature
14.	ALA4027239	A	Drug metabolism in human hepatocytes assessed as (S)-1-(3-(dimethylcarbamoyl)phenylsulfonyl)pyrrolidine-2-carboxylic acid metabolite formation at 10 uM after 60 mins by LC-MS/MS analysis	Homo sapiens	1		cell-based format	Scientific Literature
15.	ALA4027242	A	Cmax in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature
16.	ALA4027243	A	Tmax in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature
17.	ALA4027244	A	Tlast in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature
18.	ALA4027245	A	AUClast in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature
19.	ALA4027246	A	MRTlast in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature
20.	ALA4027247	A	Half life in Sprague-Dawley rat lung at 1 umol/kg, it administered as micronized powder measured up to 24 hrs post dose by electrospray LC-MS analysis	Rattus norvegicus	2		tissue-based format	Scientific Literature