# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3993768 | Binding | Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranes | Mus musculus | 42 | ALA3992534 | cell-based format | Scientific Literature | |
2. | ALA3993771 | Functional | In vivo antagonist activity at CB1R in C57Bl6/J mouse assessed as reversal of ACEA-induced reduction in upper gastrointestinal motility administered via oral gavage administered 30 mins prior to ACEA addition | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
3. | ALA3993772 | ADME | Drug level in C57Bl6/J mouse brain at 10 mg/kg, po administered via gavage measured after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
4. | ALA3993773 | ADME | Drug level in C57Bl6/J mouse brain at 10 mg/kg, po administered via gavage measured after 28 days by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
5. | ALA3993774 | ADME | Drug uptake in C57Bl6/J mouse liver at 10 mg/kg, po administered via gavage measured after 28 days by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
6. | ALA3993775 | ADME | Drug uptake in C57Bl6/J mouse liver at 10 mg/kg, po administered via gavage measured after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
7. | ALA3993776 | Functional | Antifibrotic activity in CCl4-induced C57Bl6/J mouse liver fibrosis model assessed as reduction in liver fibrosis at 10 mg/kg administered via oral gavage for 4 weeks by picrosirius red staining based histological analysis | Mus musculus | 2 | ALA3992534 | organism-based format | Scientific Literature | |
8. | ALA3993777 | ADME | Ratio of drug level in brain to plasma in C57Bl6/J mouse at 10 mg/kg, po administered via gavage measured after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
9. | ALA3993778 | ADME | Ratio of drug level in brain to plasma in C57Bl6/J mouse at 10 mg/kg, po administered via gavage measured after 28 days by LC-MS/MS analysis | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
10. | ALA3993779 | Functional | In vivo antagonist activity at CB1R in C57Bl6/J mouse assessed as induction of anxiogenic behavior at 10 mg/kg administered once daily via oral gavage for 28 days by elevated plus maze test | Mus musculus | 2 | ALA3992534 | organism-based format | Scientific Literature | |
11. | ALA3993780 | Functional | Antiobesity activity in diet-induced obesity C57Bl6/J mouse model assessed as reduction in body weight administered once daily via oral gavage for 2 weeks | Mus musculus | 1 | ALA3992534 | assay format | Scientific Literature | |
12. | ALA3993781 | Functional | Antiobesity activity in diet-induced obesity C57Bl6/J mouse model assessed as reduction in hepatic steatosis by measuring hepatic triglyceride level administered once daily via oral gavage for 2 weeks | Mus musculus | 1 | ALA3992534 | assay format | Scientific Literature | |
13. | ALA3993782 | Functional | Antifibrotic activity in CCl4-induced C57Bl6/J mouse liver fibrosis model assessed as reduction in iNOS level at 10 mg/kg administered via oral gavage for 4 weeks by immunostaining based method | Mus musculus | 2 | ALA3992534 | organism-based format | Scientific Literature | |
14. | ALA3993783 | Functional | Antiobesity activity in diet-induced obesity C57Bl6/J mouse model assessed as reduction in food intake administered once daily via oral gavage for 2 weeks | Mus musculus | 1 | ALA3992534 | assay format | Scientific Literature | |
15. | ALA3993784 | Functional | Antiobesity activity in diet-induced obesity C57Bl6/J mouse model assessed as improvement in glucose tolerance administered once daily via oral gavage for 2 weeks measured at post last dose by ipGTT | Mus musculus | 1 | ALA3992534 | assay format | Scientific Literature | |
16. | ALA3993787 | Toxicity | Mutagenicity in Salmonella typhimurium TA98 up to 125 ug/ml by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA3992534 | assay format | Scientific Literature | |
17. | ALA3993788 | Binding | Inhibition of human ERG expressed in HEK293 cells measured by Qpatch assay | Homo sapiens | 1 | ALA3992534 | cell-based format | Scientific Literature | |
18. | ALA3993789 | ADME | Tmax in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
19. | ALA3993790 | ADME | Half life in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA3992534 | organism-based format | Scientific Literature | |
20. | ALA3993791 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3992534 | organism-based format | Scientific Literature |