| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4047927 | F | In vivo inhibition of VAP-1 in Wistar rat plasma at 0.3 mg/kg, po after 6 hrs in presence of [14C]-benzylamine by liquid scintillation counting analysis relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4047930 | B | Inhibition of human VAP-1 expressed in CHO cells preincubated for 20 mins followed by [14C]-benzylamine addition measured after 1 hr by scintillation spectrometric analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 3. | ALA4047931 | P | Aqueous solubility of compound in Japanese pharmacopoeia second fluid at pH 6.8 at 130 uM after 20 hrs by HPLC analysis | 18 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4047934 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 5. | ALA4047935 | A | Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 6. | ALA4047936 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 7. | ALA4047937 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 8. | ALA4047938 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 9. | ALA4047939 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as residual activity at 5 uM after 20 mins by HPLC analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 10. | ALA4047940 | A | Inhibition of rat VAP-1 expressed in CHO cells preincubated for 20 mins followed by [14C]-benzylamine addition measured after 1 hr by scintillation spectrometric analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4047941 | F | In vivo inhibition of VAP-1 in Wistar rat plasma at 0.3 mg/kg, po after 1 hr in presence of [14C]-benzylamine by liquid scintillation counting analysis relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4047942 | A | AUC in Beagle dog at 0.2 mg/kg, iv by LC-MS/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4047943 | A | Half life in Beagle dog at 0.2 mg/kg, iv by LC-MS/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4047944 | A | AUC in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4047945 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4047946 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4047947 | A | Total clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4047948 | A | Volume of distribution at steady state in Beagle dog at 0.2 mg/kg, iv by LC-MS/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4047949 | A | Total clearance in Beagle dog at 0.2 mg/kg, iv by LC-MS/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4047950 | A | AUC in cynomolgus monkey at 0.2 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature |
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