# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3998921 | B | Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based FS-3 substrate measured every 2 mins for 1 hr by fluorescence assay | Homo sapiens | 30 | ALA3997796 | cell-based format | Scientific Literature | |
2. | ALA3998922 | B | Inhibition of recombinant human C-terminal FLAg-tagged ATX nucleotide pyrophosphate phosphatase activity expressed in baculovirus infected sf9 cells using pNP-TMP as substrate measured every 2 mins for 1 hr by fluorescence assay | Homo sapiens | 30 | ALA3997796 | cell-based format | Scientific Literature | |
3. | ALA3998923 | B | Competitive inhibition of recombinant human C-terminal FLAg-tagged ATX expressed in baculovirus infected sf9 cells using varying levels of FRET based FS-3 substrate at 0.5 to 2 times IC50 measured every 2 mins for 1 hr by Michaelis-Menten plot analysis | Homo sapiens | 6 | ALA3997796 | cell-based format | Scientific Literature | |
4. | ALA3998929 | F | Antagonist activity at LPA1 receptor (unknown origin) expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay relative to LPA | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
5. | ALA3998930 | F | Antagonist activity at LPA1 receptor (unknown origin) expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
6. | ALA3998931 | F | Antagonist activity at LPA3 receptor (unknown origin) expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
7. | ALA3998932 | F | Antagonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
8. | ALA3998933 | F | Antagonist activity at LPA4 receptor (unknown origin) expressed in CHO cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
9. | ALA3998934 | F | Antagonist activity at FLAG-tagged LPA5 receptor (unknown origin) expressed in rat B103 cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
10. | ALA3998935 | B | Inhibition of ENPP6 (unknown origin) using pNPPC as substrate measured every 2 mins for 1 hr by fluorescence assay | Homo sapiens | 30 | ALA3997796 | single protein format | Scientific Literature | |
11. | ALA3998936 | B | Inhibition of ENPP7 (unknown origin) using pNPPC as substrate measured every 2 mins for 1 hr by fluorescence assay | Homo sapiens | 30 | ALA3997796 | single protein format | Scientific Literature | |
12. | ALA3998937 | B | Inhibition of ATX (unknown origin) expressed in human A2058 cells assessed as inhibition of LPC-induced cell invasion after 20 hrs by calcein-AM dye based matrigel-mediated Boyden chamber assay | Homo sapiens | 4 | ALA3997796 | cell-based format | Scientific Literature | |
13. | ALA3998938 | B | Inhibition of ATX (unknown origin) expressed in human A2780 cells assessed as inhibition of LPC-induced cell invasion at 10 uM after 20 hrs by calcein-AM dye based matrigel-mediated Boyden chamber assay | Homo sapiens | 5 | ALA3997796 | cell-based format | Scientific Literature | |
14. | ALA3998939 | F | Antitumor activity against mouse B16F10 cells implanted in C57BL/6 mouse assessed as reduction in metastatic tumor nodules on lungs at 1 mg/kg, ip administered daily up to 10 days measured on day 21 | Mus musculus | 2 | ALA3997796 | organism-based format | Scientific Literature | |
15. | ALA3998940 | A | Stability in mouse 4T1 cells assessed as parent compound remaining at 10 uM after 16 hrs by LC-MS/MS method | Mus musculus | 4 | ALA3997796 | cell-based format | Scientific Literature | |
16. | ALA3998941 | A | Stability in mouse 4T1 cells assessed as parent compound remaining at 10 uM after 40 hrs by LC-MS/MS method | Mus musculus | 4 | ALA3997796 | cell-based format | Scientific Literature | |
17. | ALA3998944 | A | Growth inhibition of mouse 4T1 cells at 10 uM after 48 hrs by CellTiter blue assay | Mus musculus | 1 | ALA3997796 | cell-based format | Scientific Literature |