| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4042823 | A | Prodrug activation assessed as supersomal P450 oxido-reductase (unknown origin)-mediated CA4 level at 2.5 uM in presence of 0.5% O2 condition after 2 mins by HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4612120 | P | Stability of the compound in pH 7.4 potassium phosphate buffer assessed as compound hydrolysis after 48 hrs | 15 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4612121 | B | Inhibition of bovine brain tubulin polymerisation preincubated for 15 mins followed by GTP addition and measured for 20 mins by turbidimetry based spectrophotometric method | Bos taurus | 18 | assay format | Scientific Literature | ||
| 4. | ALA4612123 | B | Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 5 uM incubated for 10 mins by scintillation counting relative to control | Homo sapiens | 13 | protein complex format | Scientific Literature | ||
| 5. | ALA4612126 | B | Substrate activity at rat NADPH-cytochrome P450 oxidoreductase expressed in supersomes assessed as compound cleavage after 24 hrs in anaerobic condition by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 6. | ALA4612127 | B | Substrate activity at rat NADPH-cytochrome P450 oxidoreductase expressed in supersomes assessed as compound cleavage after 90 mins in anaerobic condition by HPLC analysis | Rattus norvegicus | 15 | assay format | Scientific Literature | ||
| 7. | ALA4612128 | F | Cytotoxicity against human A549 cells incubated for 52 hrs in oxic condition by sulforhodamine B assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 8. | ALA4612129 | F | Cytotoxicity against human A549 cells incubated for 4 hrs in anoxic condition followed by oxic exposure for 48 hrs by sulforhodamine B assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 9. | ALA4612130 | F | Ratio of GI50 for human A549 cells in oxic condition to GI50 for anoxic condition | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 10. | ALA4612131 | P | Solubility of the compound in buffered saline | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4612132 | P | Solubility of the compound in water | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4612133 | P | Solubility of the compound in DMSO | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA4612136 | F | Induction in necrosis in tumor of BALB/C mouse implanted with mouse 4T1 cells harboring firefly luciferase reporter gene at 180 mg/kg, ip measured after 72 to 96 hrs by hematoxylin and eosin staining based assay (Rvb = 46%) | Mus musculus | 1 | organism-based format | Scientific Literature |
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