# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4032161 | B | Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay | Homo sapiens | 14 | ALA4028887 | assay format | Scientific Literature | |
2. | ALA4032162 | U | Selectivity ratio of Ki for mouse macrophage iNOS expressed in Escherichia coli to Ki for rat neuronal NOS expressed in Escherichia coli | 14 | ALA4028887 | assay format | Scientific Literature | ||
3. | ALA4032163 | B | Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay | Rattus norvegicus | 14 | ALA4028887 | assay format | Scientific Literature | |
4. | ALA4032164 | A | Inhibition of mouse macrophage iNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay | Mus musculus | 14 | ALA4028887 | assay format | Scientific Literature | |
5. | ALA4032165 | A | Inhibition of human endothelial NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay | Homo sapiens | 14 | ALA4028887 | assay format | Scientific Literature | |
6. | ALA4032166 | U | Selectivity ratio of Ki for human endothelial NOS expressed in Escherichia coli to Ki for human neuronal NOS expressed in Escherichia coli | Homo sapiens | 14 | ALA4028887 | assay format | Scientific Literature | |
7. | ALA4032167 | B | Selectivity ratio of Ki for human neuronal NOS expressed in Escherichia coli to Ki for rat neuronal NOS expressed in Escherichia coli | 14 | ALA4028887 | assay format | Scientific Literature | ||
8. | ALA4032168 | P | Effective permeability of compound at 200 uM after 17 hrs by PAMPA-BBB assay | 9 | ALA4028887 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4032170 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM measured over 2 hrs by LC-MS/MS analysis | Homo sapiens | 8 | ALA4028887 | cell-based format | Scientific Literature | |
10. | ALA4032171 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM measured over 2 hrs by LC-MS/MS analysis | Homo sapiens | 8 | ALA4028887 | cell-based format | Scientific Literature | |
11. | ALA4032172 | A | Efflux ratio of apparent permeability from basolateral to apical side over apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM measured over 2 hrs by LC-MS/MS analysis | Homo sapiens | 7 | ALA4028887 | cell-based format | Scientific Literature | |
12. | ALA4032173 | A | Apparent permeability across apical to basolateral side in human Caco2 cells assessed as drug recovery at 10 uM measured over 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA4028887 | cell-based format | Scientific Literature | |
13. | ALA4032174 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as drug recovery at 10 uM measured over 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA4028887 | cell-based format | Scientific Literature | |
14. | ALA4401997 | B | Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO capture assay | Rattus norvegicus | 21 | ALA4400558 | assay format | Scientific Literature | |
15. | ALA4401998 | B | Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO capture assay | Homo sapiens | 21 | ALA4400558 | assay format | Scientific Literature | |
16. | ALA4401999 | B | Selectivity ratio of Ki for human neuronal NOS to Ki for rat neuronal NOS | 21 | ALA4400558 | assay format | Scientific Literature | ||
17. | ALA4402000 | A | Effective permeability of the compound at 200 uM after 17 hrs by PAMPA-BBB assay | 21 | ALA4400558 | assay format | Scientific Literature | ||
18. | ALA4402001 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 5 uM after 90 mins | Homo sapiens | 6 | ALA4400558 | cell-based format | Scientific Literature | |
19. | ALA4402002 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 5 uM after 90 mins | Homo sapiens | 6 | ALA4400558 | cell-based format | Scientific Literature | |
20. | ALA4402003 | A | Efflux ratio of apparent permeability in human Caco2 cells at 5 uM after 90 mins | Homo sapiens | 6 | ALA4400558 | cell-based format | Scientific Literature |