# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4011522 | Binding | Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after 30 mins by IMAP assay | Homo sapiens | 15 | ALA4007512 | single protein format | Scientific Literature | |
2. | ALA4011531 | Binding | Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assay | Homo sapiens | 15 | ALA4007512 | single protein format | Scientific Literature | |
3. | ALA4011543 | Binding | Inhibition of human ERG | Homo sapiens | 15 | ALA4007512 | single protein format | Scientific Literature | |
4. | ALA4011544 | ADME | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH by HPLC method | Homo sapiens | 15 | ALA4007512 | assay format | Scientific Literature | |
5. | ALA4011545 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM in presence of NADPH by HPLC method | Rattus norvegicus | 15 | ALA4007512 | assay format | Scientific Literature | |
6. | ALA4011546 | Toxicity | Cardiotoxicity in guinea pig assessed as QT prolongation at 1 to 10 mg/kg, iv administered via infusion | Cavia porcellus | 2 | ALA4007512 | organism-based format | Scientific Literature | |
7. | ALA4011547 | ADME | Efflux ratio in MDCK cells | Canis lupus familiaris | 2 | ALA4007512 | cell-based format | Scientific Literature | |
8. | ALA4011561 | Binding | Selectivity ratio of IC50 for human ERG to IC50 for full length GST-tagged PDE1B (unknown origin) | Homo sapiens | 1 | ALA4007512 | assay format | Scientific Literature | |
9. | ALA5226623 | Binding | Inhibition of PDE1 (unknown origin) | Homo sapiens | 3 | ALA5226285 | protein format | Scientific Literature | |
10. | ALA5226624 | Binding | Selectivity index, ratio of IC50 for PDE10 (unknown origin) to IC50 for PDE1 (unknown origin) | Homo sapiens | 2 | ALA5226285 | assay format | Scientific Literature | |
11. | ALA5226625 | Binding | Selectivity index, ratio of IC50 for human ERG to IC50 for PDE1 (unknown origin) | Homo sapiens | 1 | ALA5226285 | assay format | Scientific Literature |