# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4032476 | B | Inhibition of CDK2/cyclin A (unknown origin) at 500 nM using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATP relative to control | Homo sapiens | 34 | protein complex format | Scientific Literature | ||
2. | ALA4032477 | T | Toxicity in Swiss mouse allografted with Swiss mouse EAC cells assessed as body weight at 15 mg/kg, iv administered for 9 days measured on day 9 post last dose (Rvb = 27.9 g) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
3. | ALA4032479 | T | Toxicity in Swiss mouse allografted with Swiss mouse EAC cells assessed as body weight at 15 mg/kg, ip administered for 5 days measured on day 5 post last dose (Rvb = 27.1 g) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
4. | ALA4032480 | T | Toxicity in Swiss mouse allografted with Swiss mouse EAC cells assessed as body weight at 45 mg/kg, iv measured on day 1 (Rvb = 26.2 g) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA4032481 | F | Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
6. | ALA4032482 | F | Antiproliferative activity against human SH-SY5Y cells after 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
7. | ALA4032483 | B | Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATP | Homo sapiens | 30 | protein complex format | Scientific Literature | ||
8. | ALA4032484 | B | Inhibition of CDK9/cyclin T (unknown origin) at 500 nM using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP relative to control | Homo sapiens | 34 | protein complex format | Scientific Literature | ||
9. | ALA4032485 | B | Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP | Homo sapiens | 30 | protein complex format | Scientific Literature | ||
10. | ALA4032486 | B | Inhibition of CDK2/9 in mouse 4T1 cells assessed as decrease in Mcl-1 expression after 24 hrs by Western blot method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
11. | ALA4032487 | P | Thermodynamic equilibrium solubility of the compound in water | 6 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA4032488 | P | Thermodynamic equilibrium solubility of the compound in PBS | 6 | small-molecule physicochemical format | Scientific Literature | |||
13. | ALA4032489 | P | Thermodynamic equilibrium solubility of the compound in SGF | 6 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA4032490 | P | Thermodynamic equilibrium solubility of the compound in SIF | 6 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4032491 | A | Plasma concentration in BALB/c mouse at 2.5 mg/kg, iv at 0.083 hrs by LC/MS-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
16. | ALA4032492 | A | Plasma concentration in BALB/c mouse at 2.5 mg/kg, iv at 0.25 hrs by LC/MS-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
17. | ALA4032493 | A | Plasma concentration in BALB/c mouse at 5 mg/kg, ip at 0.25 hrs by LC/MS-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4032494 | A | Plasma concentration in BALB/c mouse at 2.5 mg/kg, iv at 0.5 hrs by LC/MS-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
19. | ALA4032495 | A | Plasma concentration in BALB/c mouse at 5 mg/kg, ip at 0.5 hrs by LC/MS-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA4032496 | A | Plasma concentration in BALB/c mouse at 2.5 mg/kg, iv at 1 hr by LC/MS-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature |