| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4039214 | Functional | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured after 1.9 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 22 | ALA4038301 | cell-based format | Scientific Literature | |
| 2. | ALA4039215 | Functional | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition measured after 1.9 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate | Rattus norvegicus | 22 | ALA4038301 | cell-based format | Scientific Literature | |
| 3. | ALA4039216 | ADME | Unbound fraction in rat plasma at 5 uM after 4 hrs by equilibrium dialysis assay | Rattus norvegicus | 11 | ALA4038301 | cell-free format | Scientific Literature | |
| 4. | ALA4039217 | ADME | Unbound fraction in human plasma at 5 uM after 4 hrs by equilibrium dialysis assay | Homo sapiens | 11 | ALA4038301 | cell-free format | Scientific Literature | |
| 5. | ALA4039218 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 6. | ALA4039219 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 7. | ALA4039220 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 8. | ALA4039221 | ADME | Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 15 | ALA4038301 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!