| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4012817 | B | Positive allosteric modulation of recombinant rat GluA1 receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method relative to glutamate | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 2. | ALA4012818 | B | Positive allosteric modulation of recombinant rat GluK2 receptor expressed in xenopus laevis oocyte assessed as potentiation of glycine-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method relative to glutamate | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 3. | ALA4012819 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 4. | ALA4012820 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2C receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 5. | ALA4012821 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2D receptor expressed in xenopus laevis oocyte assessed as potentiation of glycine-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 6. | ALA4012822 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method relative to control | Rattus norvegicus | 59 | assay format | Scientific Literature | ||
| 7. | ALA4012824 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2C receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method relative to control | Rattus norvegicus | 61 | assay format | Scientific Literature | ||
| 8. | ALA4012826 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2D receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at 30 uM at holding potential -40mV by two electrode voltage clamp method relative to control | Rattus norvegicus | 59 | assay format | Scientific Literature | ||
| 9. | ALA4012828 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 48 | assay format | Scientific Literature | ||
| 10. | ALA4012829 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2C receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 53 | assay format | Scientific Literature | ||
| 11. | ALA4012830 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2D receptor expressed in xenopus laevis oocyte assessed as potentiation of glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 44 | assay format | Scientific Literature | ||
| 12. | ALA4012831 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as compound concentration required to show two fold increase in glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 11 | assay format | Scientific Literature | ||
| 13. | ALA4012832 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2C receptor expressed in xenopus laevis oocyte assessed as compound concentration required to show two fold increase in glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 9 | assay format | Scientific Literature | ||
| 14. | ALA4012833 | B | Positive allosteric modulation of recombinant rat GluN1/GluN2D receptor expressed in xenopus laevis oocyte assessed as compound concentration required to show two fold increase in glutamate and glycine-induced current response at holding potential -40mV by two electrode voltage clamp method | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 15. | ALA4012837 | A | Cmax in C57Bl/6 mouse plasma at 10 mg/kg, ip after 2 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4012838 | A | Drug uptake in C57Bl/6 mouse brain at 10 mg/kg, ip after 15 to 30 mins by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4012839 | A | Drug uptake in C57Bl/6 mouse brain at 10 mg/kg, ip after 4 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4012840 | A | Ratio of drug level in C57Bl/6 mouse brain to plasma at 10 mg/kg, ip after 15 mins by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4012841 | A | Ratio of drug level in C57Bl/6 mouse brain to plasma at 10 mg/kg, ip after 4 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4012846 | A | Drug level in human liver microsomes treated with (3-chlorophenyl)(6-isopropoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanethione at 5.1 uM measured at 30 mins by LC/MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature |
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