| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4043777 | B | Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-based Z'-Lyte assay | Homo sapiens | 23 | ALA4043093 | assay format | Scientific Literature | |
| 2. | ALA4043778 | B | Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-based Z'-Lyte assay | Homo sapiens | 14 | ALA4043093 | assay format | Scientific Literature | |
| 3. | ALA4043779 | B | Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-based Z'-Lyte assay | Homo sapiens | 14 | ALA4043093 | assay format | Scientific Literature | |
| 4. | ALA4043780 | B | Inhibition of human recombinant His-tagged FGFR4 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-based Z'-Lyte assay | Homo sapiens | 14 | ALA4043093 | assay format | Scientific Literature | |
| 5. | ALA4043781 | F | Antiproliferative activity against human FGFR1-amplified NCI-H520 cells after 7 days by SRB assay | Homo sapiens | 15 | ALA4043093 | cell-based format | Scientific Literature | |
| 6. | ALA4043782 | F | Antiproliferative activity against human FGFR3-amplified SW780 cells after 5 days by SRB assay | Homo sapiens | 15 | ALA4043093 | cell-based format | Scientific Literature | |
| 7. | ALA4043783 | A | Cytotoxicity against human HL7702 cells assessed as cell viability after 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature | |
| 8. | ALA4043784 | B | Inhibition of FGFR2 in human FGFR2-amplified SUM52 cells assessed as decrease in FGF-induced phosphorylated ERK1/2 expression levels preincubated for 30 mins followed by FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4043093 | assay format | Scientific Literature | |
| 9. | ALA4043785 | B | Inhibition of FGFR2 in human FGFR2-amplified SUM52 cells assessed as decrease in FGF-induced FGFR2 phosphorylation levels preincubated for 30 mins followed by FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4043093 | assay format | Scientific Literature | |
| 10. | ALA4043786 | B | Inhibition of FGFR2 in human FGFR2-amplified SUM52 cells assessed as decrease in FGF-induced ERK1/2 phosphorylated expression levels at 100 nM preincubated for 30 mins followed by FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4043093 | assay format | Scientific Literature | |
| 11. | ALA4043787 | B | Inhibition of FGFR1 in human FGFR1-amplified H520 cells assessed as decrease in FGF-induced ERK1/2 phosphorylated expression levels at 100 nM preincubated for 30 mins followed by FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4043093 | assay format | Scientific Literature | |
| 12. | ALA4043788 | B | Inhibition of FGFR1 in human FGFR1-amplified H520 cells assessed as decrease in FGF-induced phosphorylated ERK1/2 expression levels at 100 nM preincubated for 30 mins followed by compound washout and incubated under drug free condition for 120 mins and subsequent FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 3 | ALA4043093 | assay format | Scientific Literature | |
| 13. | ALA4043789 | B | Inhibition of FGFR2 in human FGFR2-amplified SUM52 cells assessed as decrease in FGF-induced phosphorylated ERK1/2 expression levels at 100 nM preincubated for 30 mins followed by compound washout and incubated under drug free condition for 120 mins and subsequent FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 3 | ALA4043093 | assay format | Scientific Literature | |
| 14. | ALA4043790 | B | Inhibition of FGFR3 in human FGFR3-amplified SW780 cells assessed as decrease in FGF-induced phosphorylated ERK1/2 expression levels at 100 nM pretreated for 30 mins followed by FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 3 | ALA4043093 | assay format | Scientific Literature | |
| 15. | ALA4043791 | B | Inhibition of FGFR3 in human FGFR3-amplified SW780 cells assessed as decrease in FGF-induced phosphorylated ERK1/2 expression levels at 100 nM preincubated for 30 mins followed by compound washout and incubated under drug free condition for 120 mins and subsequent FGF stimulation measured after 15 mins by Western blot analysis | Homo sapiens | 3 | ALA4043093 | assay format | Scientific Literature | |
| 16. | ALA4043792 | F | Antiproliferative activity against human FGFR2-amplified SUM52 cells after 5 days by SRB assay | Homo sapiens | 15 | ALA4043093 | cell-based format | Scientific Literature | |
| 17. | ALA4044261 | F | Potency index, ratio of FIIN-1 IC50 to compound IC50 for human FGFR1-amplified NCI-H520 cells | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature | |
| 18. | ALA4044262 | F | Potency index, ratio of FIIN-1 IC50 to compound IC50 for human FGFR2-amplified SUM52 cells | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature | |
| 19. | ALA4044263 | F | Potency index, ratio of FIIN-1 IC50 to compound IC50 for human FGFR3-amplified SW780 cells | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature | |
| 20. | ALA4044264 | F | Antiproliferative activity against human PC9 cells after 5 days by SRB assay | Homo sapiens | 1 | ALA4043093 | cell-based format | Scientific Literature |
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