# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4055669 | B | Inhibition of recombinant full length human N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 cells using biotinylated substrate after 1 hr by UV/Vis spectrophotometric analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
2. | ALA4055670 | B | Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using biotinylated substrate after 1 hr by UV/Vis spectrophotometric analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA4055671 | B | Inhibition of HDAC1 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
4. | ALA4055672 | B | Inhibition of HDAC6 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
5. | ALA4055673 | F | Antiproliferative activity against human T47D cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
6. | ALA4055674 | F | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA4055675 | F | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA4055676 | F | Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA4055677 | F | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA4055678 | F | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
11. | ALA4055679 | F | Antiproliferative activity against human U937 cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
12. | ALA4055680 | F | Antiproliferative activity against human MDA-MB-231 cells after 5 days by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
13. | ALA4055681 | A | Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
14. | ALA4055683 | A | Safety index, ratio of compound IC50 to SAHA IC50 for human MCF10A cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4055684 | F | Antiproliferative activity against human Raji cells after 3 days by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA4055685 | F | Antiproliferative activity against human HCC1937 cells after 3 days by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
17. | ALA4055686 | F | Potency index, ratio of SAHA IC50 to compound IC50 for human Raji cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4055687 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.27%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4055688 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as late apoptotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 3.82%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4055689 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as necrotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.024%) | Homo sapiens | 2 | cell-based format | Scientific Literature |