| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4013952 | Binding | Inhibition of Norovirus 3CL protease using Edans-DFHLQ/GP-Dabcyl as substrate after 30 mins by FRET assay | Norovirus | 26 | ALA4011653 | assay format | Scientific Literature | |
| 2. | ALA4013953 | Functional | Antiviral activity against Norovirus infected in human HG23 cells assessed as inhibition of viral replication after 48 hrs by quantitative RT-PCR method | Norovirus | 26 | ALA4011653 | cell-based format | Scientific Literature | |
| 3. | ALA4013954 | Functional | Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4011653 | cell-based format | Scientific Literature | |
| 4. | ALA4013955 | Toxicity | Selectivity index, ratio of CC50 for human HG23 cells to EC50 for norovirus | 6 | ALA4011653 | assay format | Scientific Literature | ||
| 5. | ALA4013956 | ADME | Metabolic stability of human liver microsomes assessed as amount of parent compound remaining at 25 to 100 uM after 1 hr in the presence of NADPH by LC-MS method | Homo sapiens | 8 | ALA4011653 | assay format | Scientific Literature | |
| 6. | ALA4013957 | ADME | Metabolic stability of mouse liver microsomes assessed as amount of parent compound remaining at 25 to 100 uM after 1 hr in the presence of NADPH by LC-MS method | Mus musculus | 8 | ALA4011653 | assay format | Scientific Literature | |
| 7. | ALA4013958 | ADME | Protein binding in human serum at 25 to 100 uM after 4 hrs by LC-MS method | Homo sapiens | 8 | ALA4011653 | cell-free format | Scientific Literature | |
| 8. | ALA4013959 | ADME | Protein binding in mouse serum at 25 to 100 uM after 4 hrs by LC-MS method | Mus musculus | 8 | ALA4011653 | cell-free format | Scientific Literature | |
| 9. | ALA4013961 | ADME | Metabolic stability in human serum assessed as amount of parent compound remaining at 25 to 100 uM at 37 degC after 1 hr by LC-MS analysis | Homo sapiens | 5 | ALA4011653 | cell-free format | Scientific Literature | |
| 10. | ALA4013962 | ADME | Metabolic stability in mouse serum assessed as amount of parent compound remaining at 25 to 100 uM at 37 degC after 1 hr by LC-MS analysis | Mus musculus | 5 | ALA4011653 | cell-free format | Scientific Literature | |
| 11. | ALA4013964 | ADME | Prodrug activation human liver microsomes assessed as 3-chlorobenzyl (S)-3-cyclohexyl-1-oxo-1-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-ylamino)propan-2-ylcarbamate formation at 25 to 100 uM after 1 hr in the presence of NADPH by LC-MS method | Homo sapiens | 1 | ALA4011653 | assay format | Scientific Literature |
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