# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3992696 | B | Inhibition of 50% inactivated recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit at holding potential of -120 mV by manual patch electrophysiology method | Homo sapiens | 28 | ALA3992487 | cell-based format | Scientific Literature | |
2. | ALA3992697 | B | Inhibition of Cy3B-labeled ligand binding to recombinant human ERG expressed in HEK293 cells by fluorescence polarization method | Homo sapiens | 14 | ALA3992487 | cell-based format | Scientific Literature | |
3. | ALA3992698 | A | Inhibition of 50% inactivated recombinant human Nav1.5 expressed in HEK293 cells at holding potential of -150 mV by PatchXpress automated electrophysiology method | Homo sapiens | 6 | ALA3992487 | cell-based format | Scientific Literature | |
4. | ALA3992699 | B | Inhibition of 50% inactivated recombinant human Nav1.1 expressed in HEK293 cells at holding potential of -120 mV by manual patch electrophysiology method | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
5. | ALA3992700 | B | Inhibition of 50% inactivated recombinant human Nav1.2 expressed in HEK293 cells at holding potential of -120 mV by manual patch electrophysiology method | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
6. | ALA3992701 | B | Inhibition of 50% inactivated recombinant human Nav1.6 expressed in HEK293 cells at holding potential of -120 mV by manual patch electrophysiology method | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
7. | ALA3992702 | B | Inhibition of 50% inactivated recombinant human Nav1.7 expressed in HEK293 cells at holding potential of -120 mV by PatchXpress automated electrophysiology method | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
8. | ALA3992703 | U | Selectivity index, ratio of IC50 for recombinant human Nav1.5 expressed in HEK293 cells to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 3 | ALA3992487 | cell-based format | Scientific Literature | |
9. | ALA3992704 | B | Selectivity index, ratio of IC50 for recombinant human Nav1.1 expressed in HEK293 cells to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
10. | ALA3992705 | B | Selectivity index, ratio of IC50 for recombinant human Nav1.2 expressed in HEK293 cells to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
11. | ALA3992706 | B | Selectivity index, ratio of IC50 for recombinant human Nav1.6 expressed in HEK293 cells to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
12. | ALA3992707 | B | Selectivity index, ratio of IC50 for recombinant human Nav1.7 expressed in HEK293 cells to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
13. | ALA3992708 | B | Inhibition of recombinant human ERG expressed in HEK293 cells at holding potential of -120 mV by PatchXpress automated electrophysiology method | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
14. | ALA3992709 | B | Selectivity index, ratio of IC50 for recombinant human ERG expressed in HEK293 cells by PatchXpress automated electrophysiology method to IC50 for recombinant human Nav1.8 expressed in HEK293 cells coexpressing Nav beta1 subunit | Homo sapiens | 2 | ALA3992487 | cell-based format | Scientific Literature | |
15. | ALA3992710 | P | Dissociation constant, pKa of the compound | 5 | ALA3992487 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3992711 | B | Inhibition of KCNQ1 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA3992487 | single protein format | Scientific Literature | |
17. | ALA3992712 | B | Inhibition of GABA receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA3992487 | assay format | Scientific Literature | |
18. | ALA3992713 | B | Inhibition of Cav1.2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA3992487 | single protein format | Scientific Literature | |
19. | ALA3992714 | B | Inhibition of Cav3.2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA3992487 | single protein format | Scientific Literature | |
20. | ALA3992715 | A | Clearance in rat blood | Rattus norvegicus | 1 | ALA3992487 | assay format | Scientific Literature |