| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4024541 | ADME | Half life in mouse liver microsomes at 0.8 uM by LC-MS/MS analysis | Mus musculus | 48 | ALA4020847 | assay format | Scientific Literature | |
| 2. | ALA4024542 | ADME | Intrinsic clearance in mouse liver microsomes at 0.8 uM by LC-MS/MS analysis | Mus musculus | 48 | ALA4020847 | assay format | Scientific Literature | |
| 3. | ALA4222544 | Binding | Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetylated human UBE2M (1 to 12 residues) after 1 hr by TR-FRET assay | Homo sapiens | 62 | ALA4219151 | single protein format | Scientific Literature | |
| 4. | ALA4222545 | Physicochemical | Solubility of the compound at pH 7.4 after 18 hrs by UV-spectroscopy | 61 | ALA4219151 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4222546 | ADME | Permeability of the compound at 10 uM by PAMPA | 61 | ALA4219151 | assay format | Scientific Literature | ||
| 6. | ALA4222547 | Binding | Binding affinity biotinylated human GST-tagged DCN1 by ITC method | Homo sapiens | 10 | ALA4219151 | single protein format | Scientific Literature | |
| 7. | ALA4222553 | Binding | Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD measured for 10 sec by pulse-chase assay | Homo sapiens | 10 | ALA4219151 | single protein format | Scientific Literature | |
| 8. | ALA4222554 | ADME | Growth inhibition of human BJ cells | Homo sapiens | 10 | ALA4219151 | cell-based format | Scientific Literature | |
| 9. | ALA4222555 | Functional | Growth inhibition of human HCC95 cells | Homo sapiens | 10 | ALA4219151 | cell-based format | Scientific Literature |
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