# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4058595 | ADME | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv or 5 mg/kg, po by LC-MS/MS method | Mus musculus | 2 | ALA4052814 | organism-based format | Scientific Literature | |
2. | ALA4058596 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv or 5 mg/kg, po by LC-MS/MS method | Rattus norvegicus | 2 | ALA4052814 | organism-based format | Scientific Literature | |
3. | ALA4058597 | ADME | Cmax in CD-1 mouse at 1 mg/kg, iv or 5 mg/kg, po by LC-MS/MS method | Mus musculus | 2 | ALA4052814 | organism-based format | Scientific Literature | |
4. | ALA4058598 | ADME | Ratio of unbound concentration in rat brain to plasma at 250 mg/kg measured after 3 hrs postdose | Rattus norvegicus | 2 | ALA4052814 | organism-based format | Scientific Literature | |
5. | ALA4058599 | Toxicity | Neurotoxicity in rat assessed as effect on vocalization and hyperactivity at 250 mg/kg administered as single dose | Rattus norvegicus | 2 | ALA4052814 | organism-based format | Scientific Literature | |
6. | ALA4058600 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay | Homo sapiens | 21 | ALA4052814 | single protein format | Scientific Literature | |
7. | ALA4058601 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BRD4 bromodomain-1 measured after 10 mins by TR-FRET assay | Homo sapiens | 21 | ALA4052814 | single protein format | Scientific Literature | |
8. | ALA4058602 | Binding | Selectivity ratio of IC50 for human recombinant His-tagged BRD4 bromodomain-1 to IC50 for recombinant His-tagged human CBP expressed in HEK293 cells | Homo sapiens | 20 | ALA4052814 | cell-based format | Scientific Literature | |
9. | ALA4058603 | Binding | Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated human CBP expressed in HEK293 cells after overnight incubation by BRET assay | Homo sapiens | 18 | ALA4052814 | cell-based format | Scientific Literature | |
10. | ALA4058604 | Binding | Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence method | Homo sapiens | 3 | ALA4052814 | cell-based format | Scientific Literature | |
11. | ALA4058605 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged P300 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
12. | ALA4058606 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BAZ2B measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
13. | ALA4058607 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged BPTF (unknown origin) measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
14. | ALA4058608 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BRD4 bromodomain-2 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
15. | ALA4058609 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged BRD8 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
16. | ALA4058610 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BRD9 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
17. | ALA4058611 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged BRPF1 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
18. | ALA4058612 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CECR2 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
19. | ALA4058613 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged human GCN5L2 measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature | |
20. | ALA4058614 | Binding | Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged PCAF measured after 10 mins by TR-FRET assay | Homo sapiens | 2 | ALA4052814 | single protein format | Scientific Literature |