# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4000296 | Binding | Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-catenin-mediated transcriptional activity after 24 hrs by Steady-Glo luciferase assay | Homo sapiens | 16 | ALA4000145 | cell-based format | Scientific Literature | |
2. | ALA4000297 | Functional | Inhibition of beta-catenin-mediated transcriptional activity in Wnt3A knock out HEK293-STF cells preincubated for 4 hrs followed by Wnt-3A conditioned medium addition measured after 24 hrs by Steady-Glo luciferase assay | Homo sapiens | 1 | ALA4000145 | cell-based format | Scientific Literature | |
3. | ALA4000298 | ADME | Cytotoxicity against HEK293 cells assessed as cell viability after 1 day by CellTiter-Glo luminescent assay | Homo sapiens | 1 | ALA4000145 | cell-based format | Scientific Literature | |
4. | ALA4000299 | Physicochemical | Thermodynamic solubility of the compound at pH 7.4 | 4 | ALA4000145 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4000300 | Physicochemical | Permeability of the compound at pH 7.4 by PAMPA assay | 4 | ALA4000145 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4000301 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 9 | ALA4000145 | single protein format | Scientific Literature | |
7. | ALA4000302 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 9 | ALA4000145 | single protein format | Scientific Literature | |
8. | ALA4000303 | ADME | Oral bioavailability in mouse | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
9. | ALA4000304 | ADME | Intrinsic clearance in mouse liver microsomes | Mus musculus | 11 | ALA4000145 | assay format | Scientific Literature | |
10. | ALA4000305 | Binding | Inhibition of PORCN-mediated V5-tagged Wnt3A palmitoylation in human HeLa cells at 100 nM measured after over night incubation by Western blot analysis | Homo sapiens | 3 | ALA4000145 | cell-based format | Scientific Literature | |
11. | ALA4495582 | Functional | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
12. | ALA4513082 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
13. | ALA5227328 | Binding | Inhibition of mouse STF3A | Mus musculus | 5 | ALA5226302 | single protein format | Scientific Literature | |
14. | ALA5227329 | Physicochemical | Solubility of the compound at pH 7.4 | 4 | ALA5226302 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA5227330 | ADME | Permeability of the compound at pH 7.4 by PAMPA | 1 | ALA5226302 | assay format | Scientific Literature | ||
16. | ALA5227331 | ADME | Oral bioavailability in mouse at 2.5 mg/kg | Mus musculus | 3 | ALA5226302 | organism-based format | Scientific Literature |