| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4039328 | A | Cytotoxicity in BMSC (unknown origin) assessed as cell viability at 1000 nmol/L after 72 hrs by MTT assay | Not specified | 3 | ALA4038302 | cell-based format | Scientific Literature | |
| 2. | ALA4039329 | F | Induction of apoptosis in human MDA-MB-231 cells xenografted in BALB/C nude mouse at 4 umol/kg, iv administered starting on day 5 measured after day 22 by tunnel assay relative to control | Homo sapiens | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 3. | ALA4039332 | A | Invivo prodrug activation in tumor of BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L by LC-MS/MS analysis | Mus musculus | 1 | ALA4038302 | assay format | Scientific Literature | |
| 4. | ALA4039333 | A | Ratio of invivo prodrug activation in tumor of BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation in absence of talabostat to FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation in presence of talabostat at 40 umol/L by LC-MS/MS analysis | Mus musculus | 1 | ALA4038302 | assay format | Scientific Literature | |
| 5. | ALA4039334 | A | Prodrug activation in Sprague Dawley rat serum assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4038302 | assay format | Scientific Literature | |
| 6. | ALA4039335 | A | Prodrug activation in BMSC (unknown origin) assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L by LC-MS/MS analysis | Homo sapiens | 1 | ALA4038302 | single protein format | Scientific Literature | |
| 7. | ALA4039336 | A | Prodrug activation in 10% fetal bovine serum assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L by LC-MS/MS analysis | Bos taurus | 1 | ALA4038302 | single protein format | Scientific Literature | |
| 8. | ALA4039337 | A | Invivo prodrug activation in heart of of BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L by LC-MS/MS analysis | Mus musculus | 1 | ALA4038302 | tissue-based format | Scientific Literature | |
| 9. | ALA4039343 | A | Prodrug activation assessed as recombinant human FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L after 6 hrs by UPLC-MS/MS analysis | Homo sapiens | 1 | ALA4038302 | single protein format | Scientific Literature | |
| 10. | ALA4039345 | A | Prodrug activation assessed as recombinant human FAP-alpha mediated (S)-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-12-oxo-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl) 2-amino-3-(1H-indol-3-yl)propanoate formation at 40 umol/L after 6 hrs in presence of FAP-alpha inhibitor talabostat by UPLC-MS/MS analysis | Homo sapiens | 1 | ALA4038302 | single protein format | Scientific Literature | |
| 11. | ALA4039346 | T | Nephrotoxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells at 12 umol/kg, iv administered starting on day 5 measured after day 22 by hematoxylin-eosin staining-based assay | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 12. | ALA4039347 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as histopathologic change in femur at 12 umol/kg, iv administered starting on day 5 measured after day 22 by hematoxylin-eosin staining-based assay | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 13. | ALA4039348 | T | Hepatotoxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells at 12 umol/kg, iv administered starting on day 5 measured after day 22 by hematoxylin-eosin staining-based assay | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 14. | ALA4039349 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as histopathologic change in spleen at 12 umol/kg, iv administered starting on day 5 measured after day 22 by hematoxylin-eosin staining-based assay | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 15. | ALA4039350 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as histopathologic change in lungh at 12 umol/kg, iv administered starting on day 5 measured after day 22 by hematoxylin-eosin staining-based assay | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 16. | ALA4039351 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as body weight change at 12 umol/kg, iv administered starting on day 5 measured after day 22 | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 17. | ALA4039352 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as abnormal behavioral at 12 umol/kg, iv administered starting on day 5 measured after day 22 | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 18. | ALA4039353 | T | Toxicity in BALB/C nude mouse xenografted with human MDA-MB-231 cells assessed as abnormal food intake at 12 umol/kg, iv administered starting on day 5 measured after day 22 | Mus musculus | 1 | ALA4038302 | organism-based format | Scientific Literature | |
| 19. | ALA4039354 | F | Antiproliferative activity against wild type human MDA-MB-435 cells expressing FAP-alpha incubated for 48 hrs by MTT assay | Homo sapiens | 3 | ALA4038302 | cell-based format | Scientific Literature | |
| 20. | ALA4039355 | F | Antiproliferative activity against FAP-alpha deficient human MCF7 cells incubated for 48 hrs by MTT assay | Homo sapiens | 3 | ALA4038302 | cell-based format | Scientific Literature |
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