# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4056012 | B | Agonist activity at FXR in human Caco2 cells | Homo sapiens | 4 | ALA4052684 | cell-based format | Scientific Literature | |
2. | ALA4056013 | B | Agonist activity at FXR in human Hepg2 cells | Homo sapiens | 4 | ALA4052684 | cell-based format | Scientific Literature | |
3. | ALA4056015 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in BSEP mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
4. | ALA4056016 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in SHP mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
5. | ALA4056017 | B | Agonist activity at FXR in rat primary hepatocytes assessed as reduction in CYP7A1 mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
6. | ALA4056018 | A | Cytotoxicity against human Caco2 cells at 100 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA4052684 | cell-based format | Scientific Literature | |
7. | ALA4056019 | A | Drug uptake in human Caco2 cells at 20 and 50 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
8. | ALA4056020 | A | Drug uptake in human Caco2 cells at 20 and 50 uM by LC-MS/MS method after 3 hrs | Homo sapiens | 1 | ALA4052684 | cell-based format | Scientific Literature | |
9. | ALA4056022 | A | Apparent permeability from apical side to basolateral side in human Caco2 cells at 20 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
10. | ALA4056023 | A | Apparent permeability from apical side to basolateral side in human Caco2 cells at 50 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
11. | ALA4056024 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 20 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
12. | ALA4056025 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 50 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
13. | ALA4056026 | A | Efflux ratio in human Caco2 cells at 20 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
14. | ALA4056027 | A | Efflux ratio in human Caco2 cells at 50 uM by LC-MS/MS method | Homo sapiens | 2 | ALA4052684 | cell-based format | Scientific Literature | |
15. | ALA4056028 | A | Drug accumulation in C57BL/6 mouse ileum at 100 mg/kg, ig for 5 days by LC-MS/MS method | Mus musculus | 2 | ALA4052684 | organism-based format | Scientific Literature | |
16. | ALA4056032 | F | Increase in FXR mRNA expression in C57BL/6 mouse ileum at 100 mg/kg, ig for 5 days by PCR method | Mus musculus | 1 | ALA4052684 | organism-based format | Scientific Literature | |
17. | ALA4056033 | A | Effect on FXR mRNA expression in C57BL/6 mouse duodenum at 100 mg/kg, ig for 5 days by PCR method | Mus musculus | 1 | ALA4052684 | organism-based format | Scientific Literature | |
18. | ALA4056034 | A | Effect on FXR mRNA expression in C57BL/6 mouse jejunum at 100 mg/kg, ig for 5 days by PCR method | Mus musculus | 1 | ALA4052684 | organism-based format | Scientific Literature | |
19. | ALA4056035 | A | Effect on FXR mRNA expression in C57BL/6 mouse liver at 100 mg/kg, ig for 5 days by PCR method | Mus musculus | 1 | ALA4052684 | organism-based format | Scientific Literature | |
20. | ALA4056036 | A | Effect on FXR mRNA expression in C57BL/6 mouse kidney at 100 mg/kg, ig for 5 days by PCR method | Mus musculus | 1 | ALA4052684 | organism-based format | Scientific Literature |