# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4042623 | B | Inhibition of quorum sensing LasI synthase in Pseudomonas aeruginosa PAO1 harboring reporter plasmid lasB-gfp assessed as reduction in lasB expression measured every 15 mins for 12 hrs by GFP-fluorescence assay | Pseudomonas aeruginosa PAO1 | 30 | assay format | Scientific Literature | ||
2. | ALA4042624 | B | Inhibition of quorum sensing regulator protein RhlR in Pseudomonas aeruginosa PAO1 harboring reporter plasmid rhlA-gfp assessed as reduction in rhlA expression measured every 15 mins for 12 hrs by GFP-fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | assay format | Scientific Literature | ||
3. | ALA4042625 | B | Inhibition of quorum sensing regulator protein pqsR in Pseudomonas aeruginosa PAO1 harboring reporter plasmid pqsA-gfp assessed as reduction in pqsA expression measured every 15 mins for 12 hrs by GFP-fluorescence assay | Pseudomonas aeruginosa PAO1 | 1 | assay format | Scientific Literature | ||
4. | ALA4042627 | A | Growth inhibition of Pseudomonas aeruginosa PAO1 harboring reporter plasmid lasB-gfp | Pseudomonas aeruginosa | 30 | assay format | Scientific Literature | ||
5. | ALA4042628 | B | Inhibition of quorum sensing LasI synthase in wild-type Pseudomonas aeruginosa PAO1 assessed as reduction in elastase production at 10 uM incubated for 24 hrs measured every 10 mins for 3 hrs by BODIPY fluorophore-labelled DQ elastin conjugate based fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | assay format | Scientific Literature | ||
6. | ALA4042629 | B | Inhibition of quorum sensing regulator protein RhlR in wild-type Pseudomonas aeruginosa PAO1 assessed as reduction in pyocyanin level at 10 uM after 48 hrs | Pseudomonas aeruginosa PAO1 | 2 | assay format | Scientific Literature | ||
7. | ALA4042630 | B | Inhibition of quorum sensing regulator protein RhlR in wild-type Pseudomonas aeruginosa PAO1 assessed as reduction in rhamnolipid level at 10 uM after 24 hrs relative to control | Pseudomonas aeruginosa PAO1 | 2 | assay format | Scientific Literature | ||
8. | ALA4042631 | B | Inhibition of quorum sensing LasI synthase in Pseudomonas aeruginosa PAO1 harboring reporter plasmid lasB-gfp at 10 uM in presence of bovine serum albumin measured after 18 hrs by GFP-fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | assay format | Scientific Literature | ||
9. | ALA4042632 | A | Cytotoxicity against mouse RAW264.7 cells at 100 uM measured after 16 hrs by Alamar blue assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
10. | ALA4042633 | A | Cytotoxicity against mouse RAW264.7 cells at 0.01 to 10 uM measured after 16 hrs by Alamar blue assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
11. | ALA4042634 | F | Antibacterial activity against Pseudomonas aeruginosa in bacterial coated silicone implanted BALB/c mouse assessed as reduction in biofilm formation at 10 uM measured at 24 hrs post infection | Pseudomonas aeruginosa | 2 | assay format | Scientific Literature | ||
12. | ALA4042635 | F | Antibacterial activity against Pseudomonas aeruginosa infected in BALB/c mouse assessed as reduction in bacterial dissemination in spleen at 10 uM measured at 24 hrs post infection | Pseudomonas aeruginosa | 2 | assay format | Scientific Literature | ||
13. | ALA4042636 | A | Effect on GFP fluorescence output signal in Pseudomonas aeruginosa PAO1 at 10 uM measured every 15 mins for 12 hrs | Pseudomonas aeruginosa | 2 | assay format | Scientific Literature |