| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4020217 | Binding | Binding affinity to human N-terminal His6-tagged BRD4 BD1-BD2 (K57 to K550 residues) after 1 hr using alexa-647 conjugated probe by TR-FRET assay | Homo sapiens | 32 | ALA4017535 | single protein format | Scientific Literature | |
| 2. | ALA4020218 | Functional | Antiproliferative activity against human MX1 cells after 72 hrs by Cell Titer Glo assay | Homo sapiens | 32 | ALA4017535 | cell-based format | Scientific Literature | |
| 3. | ALA4020219 | ADME | Unbound intrinsic clearance in human liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by HPLC-UV-MS analysis | Homo sapiens | 30 | ALA4017535 | assay format | Scientific Literature | |
| 4. | ALA4020220 | ADME | Unbound intrinsic clearance in mouse liver microsomes | Mus musculus | 28 | ALA4017535 | assay format | Scientific Literature | |
| 5. | ALA4020221 | ADME | Unbound intrinsic clearance in rat liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by HPLC-UV-MS analysis | Rattus norvegicus | 28 | ALA4017535 | assay format | Scientific Literature | |
| 6. | ALA4020222 | ADME | Permeability in MDCK cells | Canis lupus familiaris | 30 | ALA4017535 | cell-based format | Scientific Literature | |
| 7. | ALA4020283 | Binding | Inhibition of BRD4 in human H1299 cells assessed as decrease in HPV LCR-E2-EP400-mediated transcriptional repression after 24 hrs by Bright-Glo luciferase reporter gene assay | Homo sapiens | 32 | ALA4017535 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!