# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4005249 | Binding | Inhibition of 60 mM K+ activated L-type calcium channel-mediated vasoconstriction in Sprague-Dawley rat aortic rings preincubated followed by 60 mM K+ addition | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
2. | ALA4005250 | ADME | Cytotoxicity against Sprague-Dawley rat aortic rings assessed as non-specific tissue damage at 5 to 25 uM after 30 mins by LDH release assay | Rattus norvegicus | 1 | ALA4004806 | tissue-based format | Scientific Literature | |
3. | ALA4005251 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat aortic rings assessed as reduction in phenylephrine-induced vasoconstriction at 25 uM preincubated with aortic rings followed by phenylephrine addition | Rattus norvegicus | 2 | ALA4004806 | assay format | Scientific Literature | |
4. | ALA4005252 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat aortic rings assessed as reduction in phenylephrine-induced vasoconstriction preincubated with aortic rings followed by phenylephrine addition | Rattus norvegicus | 2 | ALA4004806 | assay format | Scientific Literature | |
5. | ALA4005253 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat aortic rings assessed as reduction in 5-HT-induced vasoconstriction at 5 to 25 uM preincubated with aortic rings followed by 5-HT addition | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
6. | ALA4005254 | Binding | Inhibition of L-type calcium channel in endothelium-denuded Sprague-Dawley rat aortic rings assessed as reduction in 5-HT-induced vasoconstriction at 5 to 25 uM preincubated with aortic rings followed by 5-HT addition | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
7. | ALA4005255 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat primary VSMC assessed as reduction in 5-HT-induced MLC phosphorylation preincubated for 30 mins followed by 5-HT addition measured after 10 mins by Western blot method | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
8. | ALA4005256 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat primary VSMC assessed as reduction in 5-HT-induced calcium influx preincubated for 30 mins followed by 5-HT addition by Fura-2-AM dye based confocal microscopic method | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
9. | ALA4005257 | Binding | Inhibition of L-type calcium channel in Sprague-Dawley rat aortic rings assessed as reduction in Bay K8644-induced vasoconstriction preincubated with aortic rings followed by Bay K8644 addition | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
10. | ALA4005258 | Binding | Reversible inhibition of 5-HT activated L-type calcium channel-mediated vasoconstriction in Sprague-Dawley rat aortic rings at 25 uM preincubated with aortic rings followed by 5-HT addition and subsequent compound wash out measured after 4 hrs | Rattus norvegicus | 1 | ALA4004806 | assay format | Scientific Literature | |
11. | ALA4005260 | ADME | Cytotoxicity against Sprague-Dawley rat aortic rings assessed as non-specific tissue damage after 24 hrs by TUNEL assay | Rattus norvegicus | 1 | ALA4004806 | tissue-based format | Scientific Literature |