# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4044420 | Functional | Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cAMP addition measured after 60 mins by HTRF method | Homo sapiens | 22 | ALA4043105 | cell-based format | Scientific Literature | |
2. | ALA4044421 | Functional | Antagonist activity at mouse GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cAMP addition measured after 60 mins by HTRF method | Mus musculus | 11 | ALA4043105 | cell-based format | Scientific Literature | |
3. | ALA4044422 | Functional | Antagonist activity at rat GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cAMP addition measured after 60 mins by HTRF method | Rattus norvegicus | 11 | ALA4043105 | cell-based format | Scientific Literature | |
4. | ALA4044425 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv via bolus administration by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4043105 | organism-based format | Scientific Literature | |
5. | ALA4044426 | ADME | Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv via bolus administration by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4043105 | organism-based format | Scientific Literature | |
6. | ALA4044427 | ADME | Dose normalized AUC in Sprague-Dawley rat at 3 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4043105 | organism-based format | Scientific Literature | |
7. | ALA4044428 | ADME | Dose normalized Cmax in Sprague-Dawley rat at 1 mg/kg, iv via bolus administration or 3 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4043105 | organism-based format | Scientific Literature | |
8. | ALA4044429 | ADME | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4043105 | organism-based format | Scientific Literature |