# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4046783 | A | Metabolic stability in human hepatic microsomes assessed as parent compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 10 | ALA4043199 | assay format | Scientific Literature | |
2. | ALA4046784 | A | Metabolic stability in rat hepatic microsomes assessed as parent compound remaining at 1 uM after 30 mins in presence of NADPH by LC-MS/MS analysis relative to control | Rattus norvegicus | 10 | ALA4043199 | assay format | Scientific Literature | |
3. | ALA4046785 | P | Aqueous solubility of compound at pH 7.4 | 4 | ALA4043199 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4046786 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
5. | ALA4046787 | A | Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
6. | ALA4046788 | A | Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
7. | ALA4046789 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
8. | ALA4046790 | A | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
9. | ALA4046791 | A | Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
10. | ALA4046792 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
11. | ALA4046793 | A | Induction of CYP450 in human liver microsomes as substrate after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
12. | ALA4046794 | P | Permeability of the compound at pH 7.4 by PAMPA | 4 | ALA4043199 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4046795 | A | Substrate activity at P-gp (unknown origin) assessed as efflux ratio | Homo sapiens | 4 | ALA4043199 | assay format | Scientific Literature | |
14. | ALA4046796 | B | Inhibition of human ERG | Homo sapiens | 4 | ALA4043199 | single protein format | Scientific Literature | |
15. | ALA4427245 | F | Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as L-glutamate-induced intracellular calcium mobilization incubated for 20 mins before L-glutamate addition | Homo sapiens | 23 | ALA4425158 | cell-based format | Scientific Literature | |
16. | ALA4427246 | P | Aqueous solubility of the compound at pH 7.4 | 3 | ALA4425158 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4427247 | P | Aqueous solubility of the compound at pH 1.2 | 3 | ALA4425158 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4427248 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature | |
19. | ALA4427249 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4425158 | microsome format | Scientific Literature | |
20. | ALA4427250 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA4425158 | microsome format | Scientific Literature |