# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4037437 | Binding | Inhibition of CHK1 (unknown origin) | Homo sapiens | 31 | ALA4033783 | single protein format | Scientific Literature | |
2. | ALA4037438 | Binding | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assay | Homo sapiens | 26 | ALA4033783 | cell-based format | Scientific Literature | |
3. | ALA4037439 | Physicochemical | Aqueous solubility of the compound in pH 7.4 phosphate buffer by LC-UV analysis | 10 | ALA4033783 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4037440 | ADME | Clearance in Sprague-Dawley rat hepatic microsomes at 0.2 to 1 mM after 2 mins in presence of NADPH by HPLC analysis | Rattus norvegicus | 5 | ALA4033783 | assay format | Scientific Literature | |
5. | ALA4037443 | Binding | Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrest | Homo sapiens | 28 | ALA4033783 | cell-based format | Scientific Literature | |
6. | ALA4037444 | Functional | Antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 5 | ALA4033783 | cell-based format | Scientific Literature | |
7. | ALA4037445 | Functional | Antiproliferative activity against human SW620 cells | Homo sapiens | 5 | ALA4033783 | cell-based format | Scientific Literature | |
8. | ALA4037446 | Binding | Inhibition of CHK1 in human MDA-MB-231 cells assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | ALA4033783 | cell-based format | Scientific Literature | |
9. | ALA4037447 | Functional | Antiproliferative activity against human H460 cells harboring dominant negative p53 construct | Homo sapiens | 5 | ALA4033783 | cell-based format | Scientific Literature | |
10. | ALA4037448 | Binding | Inhibition of CHK1 in human SW620 cells assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | ALA4033783 | cell-based format | Scientific Literature | |
11. | ALA4037449 | Binding | Inhibition of CHK1 in human H460 cells harboring dominant negative p53 construct assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | ALA4033783 | cell-based format | Scientific Literature | |
12. | ALA4037450 | ADME | Half life in iv dosed mouse plasma | Mus musculus | 3 | ALA4033783 | organism-based format | Scientific Literature | |
13. | ALA4037451 | ADME | Half life in iv dosed rat plasma | Rattus norvegicus | 3 | ALA4033783 | organism-based format | Scientific Literature | |
14. | ALA4037452 | ADME | Clearance in iv dosed mouse plasma | Mus musculus | 3 | ALA4033783 | organism-based format | Scientific Literature | |
15. | ALA4037453 | ADME | Clearance in iv dosed rat plasma | Rattus norvegicus | 3 | ALA4033783 | organism-based format | Scientific Literature | |
16. | ALA4037454 | ADME | Clearance in iv dosed dog plasma | Canis lupus familiaris | 3 | ALA4033783 | organism-based format | Scientific Literature | |
17. | ALA4037455 | ADME | Half life in iv dosed dog plasma | Canis lupus familiaris | 3 | ALA4033783 | organism-based format | Scientific Literature | |
18. | ALA4037456 | ADME | Volume of distribution at steady state in iv dosed dog plasma | Canis lupus familiaris | 3 | ALA4033783 | organism-based format | Scientific Literature | |
19. | ALA4037457 | ADME | Volume of distribution at steady state in iv dosed mouse plasma | Mus musculus | 3 | ALA4033783 | organism-based format | Scientific Literature | |
20. | ALA4037458 | ADME | Volume of distribution at steady state in iv dosed rat plasma | Rattus norvegicus | 3 | ALA4033783 | organism-based format | Scientific Literature |