| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4037437 | B | Inhibition of CHK1 (unknown origin) | Homo sapiens | 31 | single protein format | Scientific Literature | ||
| 2. | ALA4037438 | B | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 3. | ALA4037439 | P | Aqueous solubility of the compound in pH 7.4 phosphate buffer by LC-UV analysis | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4037440 | A | Clearance in Sprague-Dawley rat hepatic microsomes at 0.2 to 1 mM after 2 mins in presence of NADPH by HPLC analysis | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 5. | ALA4037443 | B | Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrest | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 6. | ALA4037444 | F | Antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4037445 | F | Antiproliferative activity against human SW620 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4037446 | B | Inhibition of CHK1 in human MDA-MB-231 cells assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4037447 | F | Antiproliferative activity against human H460 cells harboring dominant negative p53 construct | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4037448 | B | Inhibition of CHK1 in human SW620 cells assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4037449 | B | Inhibition of CHK1 in human H460 cells harboring dominant negative p53 construct assessed as potentiation of gemcitabine-induced antiproliferative activity relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4037450 | A | Half life in iv dosed mouse plasma | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4037451 | A | Half life in iv dosed rat plasma | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4037452 | A | Clearance in iv dosed mouse plasma | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4037453 | A | Clearance in iv dosed rat plasma | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4037454 | A | Clearance in iv dosed dog plasma | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4037455 | A | Half life in iv dosed dog plasma | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4037456 | A | Volume of distribution at steady state in iv dosed dog plasma | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4037457 | A | Volume of distribution at steady state in iv dosed mouse plasma | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4037458 | A | Volume of distribution at steady state in iv dosed rat plasma | Rattus norvegicus | 3 | organism-based format | Scientific Literature |
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