# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4022969 | B | Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
2. | ALA4022970 | A | Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
3. | ALA4022971 | U | Selectivity ratio of IC50 for recombinant human JAK2 to IC50 for recombinant human JAK1 in presence of 1 mM ATP | Homo sapiens | 43 | assay format | Scientific Literature | ||
4. | ALA4022972 | B | Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFNalpha addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 43 | protein complex format | Scientific Literature | ||
5. | ALA4022973 | A | Inhibition of JAK2 in CD34+ human whole blood assessed as reduction in EOP induced STAT5 phosphorylation preincubated for 45 mins followed by EOP addition measured after 15 mins by flow cytometric analysis | Homo sapiens | 43 | single protein format | Scientific Literature | ||
6. | ALA4022974 | A | Apparent intrinsic clearance in human liver microsomes at 1 uM | Homo sapiens | 43 | assay format | Scientific Literature | ||
7. | ALA4022975 | P | Octanol/water phosphate buffer partition coefficient, log D of compound at pH 7.4 | 43 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4022976 | B | Inhibition of recombinant human JAK3 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
9. | ALA4022977 | B | Inhibition of recombinant human TYK2 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
10. | ALA4022978 | A | Clearance in rat at 1 mg/kg, iv or 3 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
11. | ALA4022979 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv or 3 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
12. | ALA4022980 | A | Half life in rat at 1 mg/kg, iv or 3 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
13. | ALA4022981 | A | Oral bioavailability in rat at 3 mg/kg | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
14. | ALA4022982 | P | Aqueous solubility of the compound at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4022983 | A | Apparent permeability in RRCK cells from apical to basolateral side | Canis lupus familiaris | 4 | cell-based format | Scientific Literature |