# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4009309 | Binding | Activation of BTN3A1 in human Vgamma9Vdelta2 T cells assessed as induction of interleukin 2 stimulated cell proliferation treated for 72 hrs measured on day 11 post last treatment by flow cytometry | Homo sapiens | 8 | ALA4007426 | assay format | Scientific Literature | |
2. | ALA4009310 | Binding | Potency index, ratio of HMBPP EC50 to compound EC50 for BTN3A1 in human Vgamma9Vdelta2 T cells | Homo sapiens | 7 | ALA4007426 | assay format | Scientific Literature | |
3. | ALA4009312 | Toxicity | Toxicity in human Vgamma9/Vdelta2 T cells treated for 72 hrs measured on day 11 post last treatment by flow cytometry | Homo sapiens | 7 | ALA4007426 | cell-based format | Scientific Literature | |
4. | ALA4009324 | Binding | Inhibition of HMBPP binding to recombinant C-terminal His-tagged BTN3A1 intracellular domain (unknown origin) expressed in BL21(DE) assessed as change in enthalpy of HMBPP binding at 10-fold higher dose of compound by isothermal titration calorimetry (Rvb = -52 kJ/mol) | Homo sapiens | 1 | ALA4007426 | cell-based format | Scientific Literature | |
5. | ALA4009325 | Binding | Inhibition of HMBPP binding to recombinant C-terminal His-tagged BTN3A1 intracellular domain (unknown origin) expressed in BL21(DE) assessed as change in entropy of HMBPP binding at 10-fold higher dose of compound by isothermal titration calorimetry (Rvb = 19 kJ/mol) | Homo sapiens | 1 | ALA4007426 | cell-based format | Scientific Literature | |
6. | ALA4009326 | Binding | Inhibition of HMBPP binding to recombinant C-terminal His-tagged BTN3A1 intracellular domain (unknown origin) expressed in BL21(DE) assessed as change in enthalpy of HMBPP binding at 100-fold molar excess of compound by isothermal titration calorimetry (Rvb = -52 kJ/mol) | Homo sapiens | 1 | ALA4007426 | cell-based format | Scientific Literature | |
7. | ALA4009327 | Binding | Inhibition of HMBPP binding to recombinant C-terminal His-tagged BTN3A1 intracellular domain (unknown origin) expressed in BL21(DE) assessed as change in entropy of HMBPP binding at 100-fold molar excess of compound by isothermal titration calorimetry (Rvb = 19 kJ/mol) | Homo sapiens | 1 | ALA4007426 | cell-based format | Scientific Literature | |
8. | ALA4009328 | Binding | Inhibition of HMBPP binding to recombinant C-terminal His-tagged BTN3A1 intracellular domain (unknown origin) expressed in BL21(DE) by isothermal titration calorimetry | Homo sapiens | 1 | ALA4007426 | cell-based format | Scientific Literature | |
9. | ALA4009330 | Binding | Activation of BTN3A1 in human Vgamma9Vdelta2 T cells assessed as induction of T effector cells mediated K562 cell lysis preincubated with K562 cells for 2 hrs followed by T effector cell addition measured after 4 hrs | Homo sapiens | 6 | ALA4007426 | assay format | Scientific Literature | |
10. | ALA4009331 | Binding | Potency index, ratio of HMBPP EC50 to compound EC50 for BTN3A1 in human Vgamma9Vdelta2 T cells assessed as induction of T effector cells mediated K562 cell lysis | Homo sapiens | 5 | ALA4007426 | assay format | Scientific Literature | |
11. | ALA4009332 | ADME | Antiproliferative activity against human K562 cells after 72 hrs by fluorescence spectroscopy | Homo sapiens | 6 | ALA4007426 | cell-based format | Scientific Literature |