| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4024541 | A | Half life in mouse liver microsomes at 0.8 uM by LC-MS/MS analysis | Mus musculus | 48 | ALA4020847 | assay format | Scientific Literature | |
| 2. | ALA4024542 | A | Intrinsic clearance in mouse liver microsomes at 0.8 uM by LC-MS/MS analysis | Mus musculus | 48 | ALA4020847 | assay format | Scientific Literature | |
| 3. | ALA4024543 | T | Toxicity in mouse at 0.5 to 1.5 mg/kg, iv administered as single dose up to 48 hrs | Mus musculus | 2 | ALA4020847 | organism-based format | Scientific Literature | |
| 4. | ALA4024544 | A | Half life in mouse at 0.5 to 1.5 mg/kg, iv administered as single dose | Mus musculus | 1 | ALA4020847 | organism-based format | Scientific Literature | |
| 5. | ALA4024545 | A | Clearance in mouse at 0.5 to 1.5 mg/kg, iv administered as single dose | Mus musculus | 1 | ALA4020847 | organism-based format | Scientific Literature | |
| 6. | ALA4024549 | B | Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET assay | Homo sapiens | 53 | ALA4020847 | single protein format | Scientific Literature | |
| 7. | ALA4024552 | A | Plasma concentration in mouse at 0.5 to 1.5 mg/kg, iv administered as single dose after 2 hrs | Mus musculus | 1 | ALA4020847 | organism-based format | Scientific Literature | |
| 8. | ALA4024555 | A | Volume of distribution in mouse at 0.5 to 1.5 mg/kg, iv administered as single dose | Mus musculus | 2 | ALA4020847 | organism-based format | Scientific Literature | |
| 9. | ALA4222544 | B | Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetylated human UBE2M (1 to 12 residues) after 1 hr by TR-FRET assay | Homo sapiens | 62 | ALA4219151 | single protein format | Scientific Literature | |
| 10. | ALA4222545 | P | Solubility of the compound at pH 7.4 after 18 hrs by UV-spectroscopy | 61 | ALA4219151 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA4222546 | A | Permeability of the compound at 10 uM by PAMPA | 61 | ALA4219151 | assay format | Scientific Literature | ||
| 12. | ALA4222547 | B | Binding affinity biotinylated human GST-tagged DCN1 by ITC method | Homo sapiens | 10 | ALA4219151 | single protein format | Scientific Literature | |
| 13. | ALA4222548 | B | Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD at 12.5 and 50 uM measured for 10 sec by pulse-chase assay | Homo sapiens | 1 | ALA4219151 | single protein format | Scientific Literature | |
| 14. | ALA4222549 | B | Inhibition of human DCN2-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD at 12.5 and 50 uM measured for 10 sec by pulse-chase assay | Homo sapiens | 1 | ALA4219151 | single protein format | Scientific Literature | |
| 15. | ALA4222550 | B | Inhibition of human DCN3-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD at 50 uM measured for 2 mins by pulse-chase assay | Homo sapiens | 1 | ALA4219151 | single protein format | Scientific Literature | |
| 16. | ALA4222551 | B | Inhibition of human DCN4-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD at 50 uM measured for 1 min by pulse-chase assay | Homo sapiens | 1 | ALA4219151 | single protein format | Scientific Literature | |
| 17. | ALA4222552 | B | Inhibition of human DCN5-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD at 50 uM measured for 1 min by pulse-chase assay | Homo sapiens | 1 | ALA4219151 | single protein format | Scientific Literature | |
| 18. | ALA4222553 | B | Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acetylated human UBE2M to CUL2-CTD measured for 10 sec by pulse-chase assay | Homo sapiens | 10 | ALA4219151 | single protein format | Scientific Literature | |
| 19. | ALA4222554 | A | Growth inhibition of human BJ cells | Homo sapiens | 10 | ALA4219151 | cell-based format | Scientific Literature | |
| 20. | ALA4222555 | F | Growth inhibition of human HCC95 cells | Homo sapiens | 10 | ALA4219151 | cell-based format | Scientific Literature |
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