| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4059376 | B | Inhibition of NEU1 in NEU3/NEU4 double knockout C57BL6 mouse brain homogenate up to 150 uM using 4MU-NANA as substrate after 30 mins | Mus musculus | 2 | assay format | Scientific Literature | ||
| 2. | ALA4059379 | B | Inhibition of NEU3/NEU4 in NEU1 knockout C57BL6 mouse brain homogenate assessed as residual activity using 4MU-NANA as substrate after 30 mins relative to control | Mus musculus | 1 | assay format | Scientific Literature | ||
| 3. | ALA4059380 | B | Inhibition of NEU1 in C57BL6 mouse brain homogenate assessed as residual activity at 10 uM using 4MU-NANA as substrate after 30 mins relative to control | Mus musculus | 1 | assay format | Scientific Literature | ||
| 4. | ALA4059390 | P | Effective permeability of compound at pH 7.4 after 16 hrs by PAMPA | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4059391 | P | Octanol-water partition coefficient, log D of compound at pH 7.4 at 10 uM after 2 hrs by LC-MS based shake flask analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4059392 | B | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using GM3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA4059393 | B | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using GM3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 8. | ALA4059394 | B | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 9. | ALA4059395 | B | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 10. | ALA4059396 | B | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 11. | ALA4059397 | B | Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4059398 | B | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 13. | ALA4059399 | B | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 14. | ALA4059400 | B | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 15. | ALA4059401 | B | Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 16. | ALA4059406 | B | Selectivity ratio of Ki for human N-terminal MBP-fused NEU2 expressed in Escherichia coli to Ki for human N-terminal MBP-fused NEU3 expressed in Escherichia coli | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4059407 | B | Selectivity ratio of Ki for human N-terminal MBP-fused NEU4 expressed in Escherichia coli to Ki for human N-terminal MBP-fused NEU3 expressed in Escherichia coli | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4059408 | B | Selectivity ratio of IC50 for human N-terminal MBP-fused NEU4 expressed in Escherichia coli to IC50 for human N-terminal MBP-fused NEU3 expressed in Escherichia coli | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 19. | ALA4059409 | B | Potency index, ratio of DANA IC50 to compound IC50 for human N-terminal MBP-fused NEU3 expressed in Escherichia coli using GM3 as substrate | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 20. | ALA4059410 | B | Potency index, ratio of DANA IC50 to compound IC50 for human N-terminal MBP-fused NEU4 expressed in Escherichia coli using GM3 as substrate | Homo sapiens | 2 | assay format | Scientific Literature |
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