# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3997101 | F | Antagonist activity at mouse recombinant EP4 receptor assessed as inhibition of PGE2-induced cAMP level by cell based assay | Mus musculus | 2 | ALA3994644 | cell-based format | Scientific Literature | |
2. | ALA3997102 | B | Antagonist activity at dog recombinant EP4 receptor | Canis lupus familiaris | 2 | ALA3994644 | single protein format | Scientific Literature | |
3. | ALA3997103 | F | Antagonist activity at rat recombinant EP4 receptor assessed as inhibition of PGE2-induced cAMP level by cell based assay | Rattus norvegicus | 2 | ALA3994644 | cell-based format | Scientific Literature | |
4. | ALA3997104 | B | Antagonist activity at rat recombinant EP4 receptor | Rattus norvegicus | 2 | ALA3994644 | single protein format | Scientific Literature | |
5. | ALA3997105 | B | Antagonist activity at human IP receptor | Homo sapiens | 2 | ALA3994644 | single protein format | Scientific Literature | |
6. | ALA3997106 | B | Antagonist activity at human platelet TP receptor | Homo sapiens | 2 | ALA3994644 | assay format | Scientific Literature | |
7. | ALA3997107 | F | Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay | Homo sapiens | 33 | ALA3994644 | cell-based format | Scientific Literature | |
8. | ALA3997108 | A | Half life in human liver microsomes | Homo sapiens | 8 | ALA3994644 | assay format | Scientific Literature | |
9. | ALA3997109 | P | Solubility of the compound in pH 6.5 PBS | 3 | ALA3994644 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3997110 | B | Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranes | Homo sapiens | 27 | ALA3994644 | cell-based format | Scientific Literature | |
11. | ALA3997113 | A | Apparent permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 26 | ALA3994644 | cell-based format | Scientific Literature | |
12. | ALA3997115 | B | Antagonist activity at human EP1 receptor | Homo sapiens | 27 | ALA3994644 | single protein format | Scientific Literature | |
13. | ALA3997116 | B | Antagonist activity at human EP2 receptor | Homo sapiens | 27 | ALA3994644 | single protein format | Scientific Literature | |
14. | ALA3997117 | B | Antagonist activity at human EP3 receptor | Homo sapiens | 27 | ALA3994644 | single protein format | Scientific Literature | |
15. | ALA3997118 | F | Analgesic activity in po dosed rat assessed as inhibition of carrageenan-induced mechanical hyperalgesia measured at 1 hr post dose | Rattus norvegicus | 7 | ALA3994644 | organism-based format | Scientific Literature | |
16. | ALA3997119 | B | Antagonist activity at human DP receptor | Homo sapiens | 2 | ALA3994644 | assay format | Scientific Literature | |
17. | ALA3997120 | B | Antagonist activity at human FP receptor | Homo sapiens | 2 | ALA3994644 | single protein format | Scientific Literature | |
18. | ALA3997121 | B | Selectivity ratio of Ki for human EP1 receptor to Ki for human EP4 receptor expressed in HEK293 cell membranes | Homo sapiens | 1 | ALA3994644 | cell-based format | Scientific Literature | |
19. | ALA3997122 | B | Selectivity ratio of Ki for human EP2 receptor to Ki for human EP4 receptor expressed in HEK293 cell membranes | Homo sapiens | 1 | ALA3994644 | cell-based format | Scientific Literature | |
20. | ALA3997123 | B | Selectivity ratio of Ki for human EP3 receptor to Ki for human EP4 receptor expressed in HEK293 cell membranes | Homo sapiens | 1 | ALA3994644 | cell-based format | Scientific Literature |