# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4038090 | B | Displacement of BODIPY-labeled lingand from human N-terminal 6x polyHis-tagged RORgammat LBD (261 to 494 residues) expressed in Escherichia coli BL21 after 20 mins by TR-FRET assay | Homo sapiens | 15 | ALA4033797 | assay format | Scientific Literature | |
2. | ALA4038091 | B | Inverse agonist activity at RORgammat (unknown origin) expressed in human Jurkat cells assessed as inhibition of transcriptional activity after overnight incubation by human IL-17 ROR response element driven-bright-glo luciferase reporter gene assay | Homo sapiens | 15 | ALA4033797 | cell-based format | Scientific Literature | |
3. | ALA4038092 | P | Lipophilicity, log D of the compound at pH 7.4 | 14 | ALA4033797 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4038093 | A | AUC (0 to 8 hrs) in mouse at 1 mg/kg, po administered via cassette dosing | Mus musculus | 7 | ALA4033797 | organism-based format | Scientific Literature | |
5. | ALA4038094 | A | Oral bioavailability in mouse at 1 mg/kg administered via cassette dosing | Mus musculus | 6 | ALA4033797 | organism-based format | Scientific Literature | |
6. | ALA4038098 | F | In vivo inverse agonist activity at RORgammat in po dosed C57BL/6 mouse assessed as inhibition of IL-23-induced IL-17A cytokine expression | Mus musculus | 3 | ALA4033797 | organism-based format | Scientific Literature | |
7. | ALA4370422 | B | Displacement of BODIPY-labeled-5-((2Z)-2-((1-(difluoroboryl)-3,5-dimethyl-1H-pyrrol-2-yl)-methylene)-2H-pyrrol-5-yl)-N-(2-((3,5-difluoro-4-(trimethylsilyl)-phenyl)amino)-1-(4-(methoxymethyl)phenyl)-2-oxoethyl)-pentanamide from human His-tagged RORgammaT after 120 mins by TR-FRET assay | Homo sapiens | 10 | ALA4368916 | single protein format | Scientific Literature | |
8. | ALA4370423 | B | Agonist activity at His-tagged human RORgammaT assessed as induction of biotinylated SRC-1 peptide recruitment after 1 hr by TR-FRET assay | Homo sapiens | 10 | ALA4368916 | single protein format | Scientific Literature | |
9. | ALA4370426 | B | Inverse agonist activity at human His-tagged RORgammaT assessed as biotinylated SRC-1 peptide recruitment at 1 uM after 1 hr by TR-FRET assay relative to control | Homo sapiens | 3 | ALA4368916 | single protein format | Scientific Literature | |
10. | ALA4370430 | B | Inverse agonist activity at RORgammat in mouse naive CD4+ T cells cells assessed as induction of IL17 production at 0.001 to 10 uM after 4 days by ELISA | Mus musculus | 1 | ALA4368916 | cell-based format | Scientific Literature |