# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3997510 | Binding | Inhibition of LMP2 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
2. | ALA3997511 | Binding | Inhibition of proteasome beta1 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
3. | ALA3997512 | Binding | Inhibition of LMP7 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
4. | ALA3997513 | Binding | Inhibition of proteasome beta5 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
5. | ALA3997514 | Binding | Inhibition of MECL1 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
6. | ALA3997515 | Binding | Inhibition of proteasome beta2 in human MOLT4 cell lysate after 1 hr by ELISA | Homo sapiens | 4 | ALA3994666 | assay format | Scientific Literature | |
7. | ALA3997516 | ADME | Stability in Balb/c mouse liver S9 fraction assessed as compound remaining at 1 uM incubated for 90 mins in absence of NADPH by LC-MS/MS analysis | Mus musculus | 4 | ALA3994666 | tissue-based format | Scientific Literature | |
8. | ALA3997517 | ADME | Stability in Sprague-Dawley rat liver S9 fraction assessed as compound remaining at 1 uM incubated for 90 mins in absence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA3994666 | tissue-based format | Scientific Literature | |
9. | ALA3997518 | ADME | Stability in human liver S9 fraction assessed as compound remaining at 1 uM incubated for 90 mins in absence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | ALA3994666 | tissue-based format | Scientific Literature | |
10. | ALA3997519 | Physicochemical | Solubility of the compound in phosphate buffer at pH 7.2 at 10 mg/ml after 24 hrs by UV-HPLC method | 4 | ALA3994666 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3997526 | Functional | In vivo inhibition of LMP2 in Balb/c mouse assessed as residual activity in blood at 1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
12. | ALA3997527 | Functional | In vivo inhibition of LMP7 in Balb/c mouse assessed as residual activity in blood at 1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
13. | ALA3997528 | Functional | In vivo inhibition of proteasome beta5 in Balb/c mouse assessed as residual activity in blood at 1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
14. | ALA3997529 | Functional | In vivo inhibition of LMP2 in Balb/c mouse kidney at >1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
15. | ALA3997530 | Functional | In vivo inhibition of LMP2 in Balb/c mouse heart at >1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
16. | ALA3997531 | Functional | In vivo inhibition of LMP2 in Balb/c mouse liver at >1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA relative to control | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
17. | ALA3997532 | Functional | In vivo inhibition of LMP2 in Balb/c mouse brain at >1 mg/kg, iv administered as single bolus dose using 10% EtOH/25% PEG300 formulation after 1 hr by ELISA | Mus musculus | 1 | ALA3994666 | organism-based format | Scientific Literature | |
18. | ALA3997533 | Functional | Anti-inflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-12/23 p40 production pretreated for 1 hr followed by LPS stimulation measured after 20 hrs | Homo sapiens | 3 | ALA3994666 | cell-based format | Scientific Literature | |
19. | ALA3997534 | Functional | Anti-inflammatory activity in human PBMC assessed as inhibition of LPS-induced TNF-alpha production pretreated for 1 hr followed by LPS stimulation measured after 20 hrs | Homo sapiens | 3 | ALA3994666 | cell-based format | Scientific Literature | |
20. | ALA3997535 | Functional | Anti-inflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 production pretreated for 1 hr followed by LPS stimulation measured after 20 hrs | Homo sapiens | 3 | ALA3994666 | cell-based format | Scientific Literature |