# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4029858 | B | Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation using PGH2 a substrate preincubated for 10 mins followed by substrate addition measured after 1 min | Homo sapiens | 42 | ALA4028818 | cell-based format | Scientific Literature | |
2. | ALA4029859 | B | Inhibition of mPGES-1 in human A549 cells assessed as decrease in IL1beta induced PGE2 release preincubated for 30 mins followed by IL-1beta addition after 16 to 20 hrs by HTRF method | Homo sapiens | 18 | ALA4028818 | cell-based format | Scientific Literature | |
3. | ALA4029862 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
4. | ALA4029863 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 4 | ALA4028818 | assay format | Scientific Literature | |
5. | ALA4029864 | A | Metabolic stability in Guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Cavia porcellus | 4 | ALA4028818 | assay format | Scientific Literature | |
6. | ALA4029865 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
7. | ALA4029866 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
8. | ALA4029867 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
9. | ALA4029868 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
10. | ALA4029869 | A | Protein binding in human plasma at 10 uM after 5 to 10 mins by LC-MS/SM analsysis | Homo sapiens | 4 | ALA4028818 | cell-free format | Scientific Literature | |
11. | ALA4029870 | A | Protein binding in Guinea pig plasma at 10 uM after 5 to 10 mins by LC-MS/SM analysis | Cavia porcellus | 4 | ALA4028818 | cell-free format | Scientific Literature | |
12. | ALA4029882 | A | Inhibition of CYP2C19 in human liver microsomes at 1 uM measured after 40 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
13. | ALA4029887 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM measured after 40 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
14. | ALA4029888 | A | Inhibition of CYP1A2 in human liver microsomes at 1 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
15. | ALA4029889 | A | Inhibition of CYP2D6 in human liver microsomes at 1 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
16. | ALA4029890 | A | Inhibition of CYP3A4 in human liver microsomes at 1 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
17. | ALA4029891 | A | Inhibition of CYP2C9 in human liver microsomes at 1 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature |