# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4028573 | B | Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assay | Homo sapiens | 13 | ALA4024800 | assay format | Scientific Literature | |
2. | ALA4418029 | B | Inhibition of human recombinant ACMSD1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in conversion of 3-OH-anthranilic acid into ACMS by spectrophotometry | Homo sapiens | 22 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
3. | ALA4418031 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 0.5 uM following compound replacement every 24 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
4. | ALA4418032 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 5 uM following compound replacement every 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
5. | ALA4418045 | A | Cytotoxicity in mouse AML-12 cells assessed as reduction inc ell viability at 10 nM to 300 uM incubated for 4 hrs by LDH release assay | Mus musculus | 7 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
6. | ALA4418046 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 0.01 to 300 uM incubated for 4 hrs by LDH release assay | Homo sapiens | 7 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
7. | ALA4418047 | B | Inhibition of human ERG expressed in CHO cell membranes assessed as displacement of high-affinity red fluorescent hERG channel ligand | Homo sapiens | 7 | ALA4417632 | cell-based format | Patent Bioactivity Data |